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Articles Published Processes
6/28/2019 12:22:27 PM | Browse: 935 | Download: 1656
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Received |
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2019-03-20 01:11 |
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Peer-Review Started |
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2019-03-20 02:07 |
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To Make the First Decision |
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2019-04-08 00:30 |
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Return for Revision |
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2019-04-08 06:42 |
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Revised |
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2019-04-27 05:43 |
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Second Decision |
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2019-05-30 08:33 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-06-01 13:11 |
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Articles in Press |
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2019-06-01 13:11 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-06-10 03:23 |
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Typeset the Manuscript |
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2019-06-27 08:21 |
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Publish the Manuscript Online |
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2019-06-28 12:22 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Effect of NLRC5 on activation and reversion of hepatic stellate cell by regulating nuclear factor-κB signaling pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Zhen Zhang, Jian-Ning Yao, Lian-Feng Zhang, Chun-Feng Wang, Xue-Xiu Zhang and Bing Gao |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Yan-Zhen Zhang, MD, Doctor, Doctor, Department of Second Gastroenterology, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou City, Henan Province, Zhengzhou 450052, Henan Province, China. zhangyz8848@163.com |
| Key Words |
NLRC5; Hepatic stellate cells; Liver fibrosis; Recovery |
| Core Tip |
Liver fibrosis is a pathological tissue repair process characterized by excessive deposition of extracellular matrix in the liver, accompanied by inflammation, eventually progresses to cirrhosis. Several recent reports have shown that effective treatment can reverse liver fibrosis, which is associated with inactivation of hepatic stellate cell (HSC) and multiple signaling pathways. NOD-like receptor (NLR) family, caspase activation and recruitment domain (CARD) domain containing 5/NOD27/CLR16.1 (NLRC5) is the largest member of NLRs and is highly expressed in immune tissues or organs such as spleen, lung, thymus and liver, mediating inflammation inhibition and antiviral response. This study aimed to investigate the role of NLRC5 in activating and devitalization of HSC and its mechanism. The results demonstrate that NLRC5 may be involved in the development and reversal of liver fibrosis by negative regulation of nuclear factor-κB. |
| Publish Date |
2019-06-28 12:22 |
| Citation |
Zhang YZ, Yao JN, Zhang LF, Wang CF, Zhang XX, Gao B. Effect of NLRC5 on activation and reversion of hepatic stellate cell by regulating nuclear factor-κB signaling pathway. World J Gastroenterol 2019; 25(24): 3044-3055 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i24/3044.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i24.3044 |
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