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10/22/2019 7:13:54 AM | Browse: 663 | Download: 757
Publication Name World Journal of Stem Cells
Manuscript ID 47706
Country/Territory Spain
Received
2019-03-26 01:30
Peer-Review Started
2019-03-28 09:08
To Make the First Decision
2019-06-05 06:12
Return for Revision
2019-06-17 02:18
Revised
2019-07-15 06:23
Second Decision
2019-07-23 06:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-07-29 18:42
Articles in Press
2019-07-29 18:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-08-14 02:22
Typeset the Manuscript
2019-09-29 02:40
Publish the Manuscript Online
2019-10-22 07:13
ISSN 1948-0210 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Review
Article Title Enhancing the survival, engraftment and osteogenic potential of mesenchymal stem cells
Manuscript Source Invited Manuscript
All Author List Daniel García-Sánchez, Darío Fernández, José C Rodríguez-Rey and Flor M Pérez-Campo
ORCID
Author(s) ORCID Number
Daniel García-Sánchez http://orcid.org/0000-0002-1754-9185
Darío Fernández http://orcid.org/0000-0002-9763-7328
José C Rodríguez-Rey http://orcid.org/0000-0002-8369-3118
Flor M Pérez-Campo http://orcid.org/0000-0002-9872-7990
Funding Agency and Grant Number
Corresponding Author Flor M Pérez-Campo, BSc, MSc, PhD, Assistant Professor, Senior Statistician, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Cantabria, Avda Cardenal Herrera Oria S/N, Cantabria 39011, Spain. f.perezcampo@unican.es
Key Words Mesenchymal stem cells; Bone regeneration; Hypoxia; Anoikis; Preconditioning; Bioactive scaffolds
Core Tip Mesenchymal stem cells (MSCs) are important tools for a wide range of therapeutic applications, including the treatment of critical size fractures or bone defects. However, whereas early clinical studies showed great expectations, long-term benefits of MSC-based treatments are not entirely successful. Transplanted cells had to face a series of important challenges that greatly reduce their survival and engraftment, and thus, their capacity of regenerating the target tissue. Although there is solid data indicating that the paracrine actions exerted by MSCs are equally important in the outcome of the treatment, this review is based on the current strategies aimed to enhance the tissue regeneration directly occurring from the engraftment and differentiation of the transplanted MSCs.
Publish Date 2019-10-22 07:13
Citation Garcia-Sanchez D, Fernandez D, Rodriguez-Rey JC, Perez-Campo FM. Enhancing the survival, engraftment and osteogenic potential of mesenchymal stem cells. World J Stem Cell 2019; 11(10):748-763
URL https://www.wjgnet.com/1948-0210/full/v11/i10/748.htm
DOI https://dx.doi.org/10.4252/wjsc.v11.i10.748
Full Article (PDF) WJSC-11-748.pdf
Full Article (Word) WJSC-11-748.docx
Manuscript File 47706-Review_Edited.docx
Answering Reviewers 47706-Answering reviewers.pdf
Audio Core Tip 47706-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 47706-Conflict-of-interest statement.pdf
Copyright License Agreement 47706-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 47706-Language certificate.pdf
Peer-review Report 47706-Peer-review(s).pdf
Scientific Misconduct Check 47706-Scientific misconduct check.pdf
Scientific Editor Work List 47706-Scientific editor work list.pdf