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Articles Published Processes
10/22/2019 7:13:54 AM | Browse: 824 | Download: 1085
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Received |
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2019-03-26 01:30 |
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Peer-Review Started |
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2019-03-28 09:08 |
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To Make the First Decision |
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2019-06-05 06:12 |
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Return for Revision |
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2019-06-17 02:18 |
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Revised |
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2019-07-15 06:23 |
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Second Decision |
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2019-07-23 06:32 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-07-29 18:42 |
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Articles in Press |
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2019-07-29 18:42 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-08-14 02:22 |
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Typeset the Manuscript |
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2019-09-29 02:40 |
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Publish the Manuscript Online |
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2019-10-22 07:13 |
| ISSN |
1948-0210 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Review |
| Article Title |
Enhancing the survival, engraftment and osteogenic potential of mesenchymal stem cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Daniel García-Sánchez, Darío Fernández, José C Rodríguez-Rey and Flor M Pérez-Campo |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Flor M Pérez-Campo, BSc, MSc, PhD, Assistant Professor, Senior Statistician, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Cantabria, Avda Cardenal Herrera Oria S/N, Cantabria 39011, Spain. f.perezcampo@unican.es |
| Key Words |
Mesenchymal stem cells; Bone regeneration; Hypoxia; Anoikis; Preconditioning; Bioactive scaffolds |
| Core Tip |
Mesenchymal stem cells (MSCs) are important tools for a wide range of therapeutic applications, including the treatment of critical size fractures or bone defects. However, whereas early clinical studies showed great expectations, long-term benefits of MSC-based treatments are not entirely successful. Transplanted cells had to face a series of important challenges that greatly reduce their survival and engraftment, and thus, their capacity of regenerating the target tissue. Although there is solid data indicating that the paracrine actions exerted by MSCs are equally important in the outcome of the treatment, this review is based on the current strategies aimed to enhance the tissue regeneration directly occurring from the engraftment and differentiation of the transplanted MSCs. |
| Publish Date |
2019-10-22 07:13 |
| Citation |
Garcia-Sanchez D, Fernandez D, Rodriguez-Rey JC, Perez-Campo FM. Enhancing the survival, engraftment and osteogenic potential of mesenchymal stem cells. World J Stem Cell 2019; 11(10):748-763 |
| URL |
https://www.wjgnet.com/1948-0210/full/v11/i10/748.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v11.i10.748 |
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