| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Plasma Nogo-A and placental growth factor levels are associated with portal hypertension in patients with liver cirrhosis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Sigita Gelman, Violeta Salteniene, Andrius Pranculis, Jurgita Skieceviciene, Romanas Zykus, Dalius Petrauskas, Limas Kupcinskas, Ali Canbay, Alexander Link and Juozas Kupcinskas |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Juozas Kupcinskas, MD, PhD, Doctor, Doctor, Professor, Research Fellow, Senior Researcher, Senior Scientist, Institute for Digestive Research, Lithuanian University of Health Sciences, A. Mickeviciaus Str. 9, Kaunas 44307, Lithuania. juozas.kupcinskas@lsmuni.lt |
| Key Words |
Liver cirrhosis; Portal hypertension; Angiogenesis; Placental growth factor; Nogo-A; Hepatic venous pressure gradient |
| Core Tip |
In this study, we aimed to evaluate plasma levels of angiogenesis mediators placental growth factor and Nogo-A protein in patients with liver cirrhosis, clinically significant portal hypertension, severe portal hypertension as well as biomarker potential to predict clinically significant and severe portal hypertension. Higher levels of placental growth factor have previously been associated with portal hypertension in animal models; however, data in patients with liver cirrhosis are scarce. To date this is the first study to evaluate Nogo-A protein levels in patients with liver cirrhosis and portal hypertension. Furthermore, to our best knowledge this is the first study to evaluate prognostic potential of these biomarkers to detect clinically significant and severe portal hypertension. We believe that this study adds additional knowledge on the complex pathogenesis of portal hypertension and might provide new insights for future research of new diagnostic approaches and treatment targets in the field. |
| Publish Date |
2019-06-21 03:42 |
| Citation |
Gelman S, Salteniene V, Pranculis A, Skieceviciene J, Zykus R, Petrauskas D, Kupcinskas L, Canbay A, Link A, Kupcinskas J. Plasma Nogo-A and placental growth factor levels are associated with portal hypertension in patients with liver cirrhosis. World J Gastroenterol 2019; 25(23): 2935-2946 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i23/2935.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i23.2935 |
