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Articles Published Processes
11/28/2019 8:04:08 AM | Browse: 949 | Download: 1149
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Received |
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2019-03-26 01:27 |
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Peer-Review Started |
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2019-03-28 09:10 |
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To Make the First Decision |
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2019-04-16 07:48 |
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Return for Revision |
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2019-05-13 03:10 |
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Revised |
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2019-09-13 18:28 |
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Second Decision |
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2019-10-14 08:59 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-10-14 18:08 |
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Articles in Press |
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2019-10-14 18:08 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-11-13 05:43 |
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Publish the Manuscript Online |
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2019-11-28 08:04 |
| ISSN |
1948-0210 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Review |
| Article Title |
Small molecules for mesenchymal stem cell fate determination
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yu-Hao Cheng, Jing-Cheng Dong and Qin Bian |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81573992 |
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| Corresponding Author |
Qin Bian, MD, PhD, Professor, The Institutes of Integrative Medicine, Fudan University, No. 12 Middle Urumqi Road, Shanghai 200040, China. qbian1@jhmi.edu |
| Key Words |
Mesenchymal stem cell; Mesenchymal stromal cell; Cell fate determination; Small molecules; Natural compounds; Signaling pathways |
| Core Tip |
Mesenchymal stem cells (MSCs), also called MSCs, are adult stem cells with multilineage differentiation potential. They serve crucial physiological roles, regulating the bone marrow microenvironment and adipose tissue remodeling in vivo. A complex regulatory network and signaling pathways are involved in governing MSC fate commitment. Much progress has been made in recent years in discovering small molecules and their underlying mechanisms that control the cell fate of MSCs. In this review, we summarize recent findings in applying small molecules to the trilineage cell fate commitment of MSCs, highlighting the underlying mechanisms and the current clinical trials. The small molecules for MSC fate determination offer substantial insights into bone marrow and adipose tissue homeostasis and therapeutic strategies for MSC-related diseases. |
| Publish Date |
2019-11-28 08:04 |
| Citation |
Cheng YH, Dong JC, Bian Q. Small molecules for mesenchymal stem cell fate determination. World J Stem Cells 2019; 11(12): 1084-1103 |
| URL |
https://www.wjgnet.com/1948-0210/full/v11/i12/1084.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v11.i12.1084 |
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