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Articles Published Processes
7/19/2019 12:39:13 PM | Browse: 962 | Download: 1850
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Received |
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2019-03-25 06:13 |
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Peer-Review Started |
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2019-03-26 03:10 |
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To Make the First Decision |
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2019-05-17 00:23 |
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Return for Revision |
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2019-05-24 06:16 |
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Revised |
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2019-05-30 11:04 |
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Second Decision |
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2019-06-05 10:36 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-06-08 14:59 |
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Articles in Press |
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2019-06-08 14:59 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-06-21 21:34 |
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Typeset the Manuscript |
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2019-07-17 00:52 |
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Publish the Manuscript Online |
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2019-07-19 12:39 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Lingguizhugan decoction attenuates diet-induced obesity and hepatosteatosis via gut microbiota
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Meng-Ting Liu, Ying-Juan Huang, Ting-Ying Zhang, Lun-Bo Tan, Xi-Feng Lu and Jian Qin |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Natural Science Foundation of China |
No.81874498 |
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| Corresponding Author |
Jian Qin, MD, PhD, Doctor, Doctor, Professor, Department of Traditional Chinese Medicine, the Seventh Affiliated Hospital of Sun Yat-Sen University, No. 628, Zhenyuan Road, Guangming New District, Shenzhen 510080, Guangdong Province, China. jian.qin.sunyatsen@outlook.com |
| Key Words |
Obesity; Diabetes; Lipid metabolism; Hepatosteatosis; Gut microbiota |
| Core Tip |
This study shows that caloric restriction (CR) together with Lingguizhugan decoction (LZD) only slightly reduce body weight and blood glucose levels of normal diet (ND)-fed mice. Yet, transplanting the fecal microbiota of these mice into high-fat diet (HFD)-fed mice potently attenuated diet-induced obesity, hepatic steatosis, and hyperglycemia. Moreover, we found that fecal microbiota transplantation (FMT) increases oxygen consumption rate of the mice and suppresses hepatic lipid biosynthesis. Using metagenomic sequencing, we further discovered that CR and LZD treatment alters the profile of ND-fed mice, and FMT alters HFD-induced changes in gut microbiota. Taken together, our study highlights that CR and LZD treatment exerts its metabolic improving effects via modulating gut microbiota. |
| Publish Date |
2019-07-19 12:39 |
| Citation |
Liu MT, Huang YJ, Zhang TY, Tan LB, Lu XF, Qin J. Lingguizhugan decoction attenuates diet-induced obesity and hepatosteatosis via gut microbiota. World J Gastroenterol 2019; 25(27): 3590-3606 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i27/3590.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i27.3590 |
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