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Articles Published Processes
8/14/2019 1:31:33 PM | Browse: 969 | Download: 1439
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Received |
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2019-03-27 02:21 |
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Peer-Review Started |
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2019-03-28 04:07 |
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To Make the First Decision |
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2019-05-31 01:01 |
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Return for Revision |
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2019-06-05 09:01 |
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Revised |
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2019-06-14 01:03 |
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Second Decision |
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2019-07-09 09:18 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-07-19 16:05 |
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Articles in Press |
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2019-07-19 16:05 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-08-07 08:55 |
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Publish the Manuscript Online |
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2019-08-14 13:31 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019 Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Intestinal enteroids/organoids: A novel platform for drug discovery in inflammatory bowel diseases
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jun Hwan Yoo and Mark Donowitz |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Basic Science Research Program through the National Research Foundation of Korea |
2015R1C1A1A02037048 |
| National Research Foundation of Korea |
2019R1H1A1035601 |
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| Corresponding Author |
Jun Hwan Yoo, MD, PhD, Assistant Professor, Digestive Disease Center, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam 13496, South Korea. jhyoo@cha.ac.kr |
| Key Words |
Enteroids; Organoids; Inflammatory bowel diseases; Crohn’s disease; Ulcerative colitis; |
| Core Tip |
Although intestinal epithelial cells are regarded as crucial regulators of barrier function in the pathogenesis of inflammatory bowel diseases (IBD), the development of novel IBD drugs targeting intestinal barrier dysfunction has been hampered by the lack of long-term human intestinal epithelial cultures. Novel intestinal enteroids/organoids derived from adult intestinal stem cells, are expected to play an important role in developing novel drugs for diverse intestinal diseases. The main purpose of this review is to provide the current status of therapeutic approaches in IBD and to highlight the potential to use human enteroids/organoids as a platform to develop novel drugs for IBD. |
| Publish Date |
2019-08-14 13:31 |
| Citation |
Yoo JH, Donowitz M. Intestinal enteroids/organoids: A novel platform for drug discovery in inflammatory bowel diseases. World J Gastroenterol 2019; 25(30): 4125-4147 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i30/4125.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i30.4125 |
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