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8/14/2019 1:31:33 PM | Browse: 808 | Download: 1120
Publication Name World Journal of Gastroenterology
Manuscript ID 47858
Country/Territory South Korea
Received
2019-03-27 02:21
Peer-Review Started
2019-03-28 04:07
To Make the First Decision
2019-05-31 01:01
Return for Revision
2019-06-05 09:01
Revised
2019-06-14 01:03
Second Decision
2019-07-09 09:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-07-19 16:05
Articles in Press
2019-07-19 16:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-08-07 08:55
Publish the Manuscript Online
2019-08-14 13:31
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019 Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Intestinal enteroids/organoids: A novel platform for drug discovery in inflammatory bowel diseases
Manuscript Source Invited Manuscript
All Author List Jun Hwan Yoo and Mark Donowitz
ORCID
Author(s) ORCID Number
Jun Hwan Yoo http://orcid.org/0000-0002-5810-4019
Mark Donowitz http://orcid.org/0000-0003-0477-8824
Funding Agency and Grant Number
Funding Agency Grant Number
Basic Science Research Program through the National Research Foundation of Korea 2015R1C1A1A02037048
National Research Foundation of Korea 2019R1H1A1035601
Corresponding Author Jun Hwan Yoo, MD, PhD, Assistant Professor, Digestive Disease Center, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam 13496, South Korea. jhyoo@cha.ac.kr
Key Words Enteroids; Organoids; Inflammatory bowel diseases; Crohn’s disease; Ulcerative colitis;
Core Tip Although intestinal epithelial cells are regarded as crucial regulators of barrier function in the pathogenesis of inflammatory bowel diseases (IBD), the development of novel IBD drugs targeting intestinal barrier dysfunction has been hampered by the lack of long-term human intestinal epithelial cultures. Novel intestinal enteroids/organoids derived from adult intestinal stem cells, are expected to play an important role in developing novel drugs for diverse intestinal diseases. The main purpose of this review is to provide the current status of therapeutic approaches in IBD and to highlight the potential to use human enteroids/organoids as a platform to develop novel drugs for IBD.
Publish Date 2019-08-14 13:31
Citation Yoo JH, Donowitz M. Intestinal enteroids/organoids: A novel platform for drug discovery in inflammatory bowel diseases. World J Gastroenterol 2019; 25(30): 4125-4147
URL https://www.wjgnet.com/1007-9327/full/v25/i30/4125.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i30.4125
Full Article (PDF) WJG-25-4125.pdf
Full Article (Word) WJG-25-4125.docx
Manuscript File 47858-Review.docx
Answering Reviewers 47858-Answering reviewers.pdf
Audio Core Tip 47858-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 47858-Conflict-of-interest statement.pdf
Copyright License Agreement 47858-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 47858-Grant application form(s).pdf
Peer-review Report 47858-Peer-review(s).pdf
Scientific Misconduct Check 47858-Scientific misconduct check.pdf
Scientific Editor Work List 47858-Scientific editor work list.pdf