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Publication Name World Journal of Gastroenterology
Manuscript ID 48011
Country/Territory United States
2019-04-06 07:45
Peer-Review Started
2019-04-08 01:56
To Make the First Decision
2019-05-31 00:30
Return for Revision
2019-05-31 01:56
2019-06-12 19:08
Second Decision
2019-06-17 10:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-06-23 01:54
Articles in Press
2019-06-23 01:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-07-03 21:40
Typeset the Manuscript
2019-07-26 06:50
Publish the Manuscript Online
2019-07-28 10:51
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Opinion Review
Article Title Importance of fatigue and its measurement in chronic liver disease
Manuscript Source Invited Manuscript
All Author List Lynn H Gerber, Ali A Weinstein, Rohini Mehta and Zobair M Younossi
Author(s) ORCID Number
Lynn H Gerber http://orcid.org/0000-0001-7525-680x
Ali A Weinstein http://orcid.org/0000-0002-3371-6086
Rohini Mehta http://orcid.org/0000-0001-5046-336x
Zobair M Younossi http://orcid.org/0000-0001-9313-577x
Funding Agency and Grant Number
Corresponding author Lynn H Gerber, MD, Professor, Director of Research, Department of Medicine, Fairfax Medical Campus, Inova Health System, 3300 Gallows Rd, Falls Church, VA22042, United States. ngerber1@gmu.edu
Keywords Fatigue; Chronic liver disease; Non-alcoholic fatty liver diseases; Non-alcoholic steatohepatitis; Measurement; Patient-reported outcomes
Core Tip Fatigue is prevalent, persistent and complex in people with non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH). Fatigue can be analyzed in terms of peripheral and central fatigue, increasing precision of evaluation while elucidating causes and improving treatment. Liver is central to the pathogenesis of fatigue, which in our view, is dependent upon energy regulation. Biosignatures for fatigue are being tested that reflect metabolic and inflammatory pathways of relevance. Non-pharmacological treatments are effective in treating fatigue in NAFLD/NASH, including weight loss, aerobic and resistance exercise. Pharmacological agents, to date, have not been shown to have a significant/reliable effect in reducing fatigue.
Publish Date 2019-07-28 10:51
Citation Gerber LH, Weinstein AA, Mehta R, Younossi ZM. Importance of fatigue and its measurement in chronic liver disease. World J Gastroenterol 2019; 25(28): 3669-3683
Url https://www.wjgnet.com/1007-9327/full/v25/i28/3669.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i28.3669
Full Article (PDF) WJG-25-3669.pdf
Full Article (Word) WJG-25-3669.docx
Manuscript File FP6891_de16_CE1MS_edt_LG_7_2.docx
Answering Reviewers 48011-Answering reviewers.pdf
Audio Core Tip 48011-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 48011-Conflict-of-interest statement.pdf
Copyright License Agreement 48011-Copyright license agreement.pdf
Peer-review Report 48011-Peer-review(s).pdf
Scientific Misconduct Check 48011-Google-MA RY-1.png
Scientific Misconduct Check 48011-Google-MA RY-2.png
Scientific Misconduct Check 48011-Scientific misconduct check.pdf
Scientific Editor Work List 48011-Scientific editor work list.pdf