Publication Name	World Journal of Gastroenterology
Manuscript ID	48062
Country	China

Received	2019-04-04 00:38
Peer-Review Started	2019-04-04 00:52
To Make the First Decision	2019-04-11 08:53
Return for Revision	2019-04-12 01:24
Revised	2019-04-27 04:58
Second Decision	2019-05-17 09:10
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2019-05-18 12:41
Articles in Press	2019-05-18 12:41
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-05-30 23:01
Typeset the Manuscript	2019-06-19 03:51
Publish the Manuscript Online	2019-06-21 03:42

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	NIMA related kinase 2 promotes gastric carcinoma cells proliferation via ERK/MAPK signaling
Manuscript Source	Unsolicited Manuscript
All Author List	Wei-Dong Fan, Tao Chen and Peng-Jun Liu
ORCID	Author(s) ORCID Number Wei-Dong Fan http://orcid.org/0000-0002-8545-150X Tao Chen http://orcid.org/0000-0001-5276-3913 Peng-Jun Liu http://orcid.org/0000-0002-6700-9072
Funding Agency and Grant Number
Corresponding Author	Peng-Jun Liu, MD, Attending Doctor, Chief Doctor, Department of Gastroenterology, the Wujin Hospital Affiliated to Jiangsu University, No. 2 Yongning north Road, Changzhou 213002, Jiangsu Province, China. liupengjun800@163.com
Key Words	NIMA related kinase 2; ERK/MAPK signaling; Cyclin D1; Cell proliferation; Gastric cancer
Core Tip	Expression of NIMA related kinase 2 (NEK2) is significantly upregulated in human gastric cancer (GC) tissues and cells. Furthermore, combined NEK2 and ERK expressions may predict overall survival in patients with GC. Surprisingly, NEK2 regulates the expression of Cyclin D1 by affecting the phosphorylation of ERK and c-JUN in GC and mediates cell proliferation via ERK/c-JUN/Cyclin D1 axis.
Publish Date	2019-06-21 03:42
Citation	Fan WD, Chen T, Liu PJ. NIMA related kinase 2 promotes gastric carcinoma cells proliferation via ERK/MAPK signaling. World J Gastroenterol 2019; 25(23): 2898-2910
URL	https://www.wjgnet.com/1007-9327/full/v25/i23/2898.htm
DOI	https://dx.doi.org/10.3748/wjg.v25.i23.2898

Full Article (PDF)	WJG-25-2898.pdf
Full Article (Word)	WJG-25-2898.docx
Manuscript File	48062-Review_Edited.docx
Answering Reviewers	48062-Answering reviewers.pdf
Audio Core Tip	48062-Audio core tip.mp3
Biostatistics Review Certificate	48062-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	48062-Conflict-of-interest statement.pdf
Copyright License Agreement	48062-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document	48062-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	48062-Language certificate.pdf
Peer-review Report	48062-Peer-review(s).pdf
Scientific Misconduct Check	48062-Google-MA RY-1.png
Scientific Misconduct Check	48062-Google-MA RY-2.png
Scientific Misconduct Check	48062-Scientific misconduct check.pdf
Scientific Editor Work List	48062-Scientific editor work list.pdf
CrossCheck Report	48062-CrossCheck report.pdf