Publication Name	World Journal of Gastroenterology
Manuscript ID	4809
Country	Japan

Received	2013-07-25 08:51
Peer-Review Started	2013-07-25 16:38
To Make the First Decision	2013-09-27 16:31
Return for Revision	2013-09-30 11:01
Revised	2013-10-22 22:07
Second Decision	2013-11-29 10:52
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-29 23:52
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-05-21 17:50
Publish the Manuscript Online	2014-06-06 16:55

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Transplantation
Manuscript Type	Autobiography
Article Title	Protocol liver biopsy is the only examination that can detect mid-term graft fibrosis after pediatric liver transplantation
Manuscript Source	Invited Manuscript
All Author List	Yukihiro Sanada, Koshi Matsumoto, Taizen Urahashi, Yoshiyuki Ihara, Taiichi Wakiya, Noriki Okada, Naoya Yamada, Yuta Hirata and Koichi Mizuta
Funding Agency and Grant Number
Corresponding Author	Yukihiro Sanada, MD, PhD, Department of Transplant Surgery, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke City, Tochigi 329-0498, Japan. yuki371@jichi.ac.jp
Key Words	Protocol liver biopsy; Graft fibrosis; Immunosuppression; Liver function test; Pediatric liver transplantation
Core Tip	Few studies have investigated the impact of the timing and effectiveness of post-transplant protocol liver biopsy (PLB). We assessed the histopathological findings of these biopsies using the Metavir scoring system, and our results clarified the timing and effectiveness of PLB. PLB at two years after pediatric liver transplantation is an unnecessary examination, because the serum alanine amino transaminase (ALT) level reflects portal inflammation. In addition, immunosuppressive therapy should be modulated to maintain the ALT concentration at a level less than 20 IU/L. PLB at five years is an excellent examination for the detection of early reversible graft fibrosis because no serum markers reflect this finding.
Publish Date	2014-06-06 16:55
Citation	Sanada Y, Matsumoto K, Urahashi T, Ihara Y, Wakiya T, Okada N, Yamada N, Hirata Y, Mizuta K. Protocol liver biopsy is the only examination that can detect mid-term graft fibrosis after pediatric liver transplantation. World J Gastroenterol 2014; 20(21): 6638-6650
URL	http://www.wjgnet.com/1007-9327/full/v20/i21/6638.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i21.6638

Full Article (PDF)	WJG-20-6638.pdf
Full Article (Word)	WJG-20-6638.doc
Manuscript File	4809-Review.doc
Answering Reviewers	4809-Answering reviewers.pdf
Copyright License Agreement	4809-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4809-Language certificate.pdf
Peer-review Report	4809-Peer review(s).pdf
Scientific Editor Work List	4809-Scientific editor work list.doc