| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which selected by an in-house editor and fully peer-reviewed by external reviewers. It distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Genomic profile concordance between pancreatic cyst fluid and neoplastic tissue
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Arthur Laquiere, Arnaud Lagarde, Bertrand Napoleon, Raphaël Bourdariat, Alexandre Atkinson, Gianfranco Donatelli, Bernard Pol, Laurence Lecomte, Laurence Curel, Romina Urena Campos, Thierry Helbert, Vincent Valantin, François Mithieux, Jean Pascal Buono, Philippe Grandval and Sylviane Olschwang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Arthur Laquiere, MD, Department of Gastroenterology, Saint Joseph Hospital, 26 bd de Louvain, Marseille 13008, France. alaquiere@hopital-saint-joseph.fr |
| Key Words |
Pancreatic cancer; Pancreatic cystic neoplasms; Pancreatic adenocarcinoma; Malignancy prediction; Neoplastic surgical tissue; Pancreatic cystic fluid |
| Core Tip |
This pilot study (20 patients) was a comparative next-generation sequencing mutational analysis between pancreatic cyst fluid (CF) and neoplastic surgical tissue (NT) to confirm whether the CF genomic profile was a reliable malignancy predictor. Concordant genotypes were found in 15 of 17 paired DNA samples. The sensitivity and specificity of CF mutations to predict an appropriate indication for surgical resection were 0.78 and 0.62 for the KRAS/GNAS mutations and 0.55 and 1.0 for the RAF/PTPRD/CTNNB1/RNF43/POLD1/TP53 mutations, respectively. Mutational analyses of CF and NT were highly concordant, confirming the interest of CF NGS analysis in the preoperative malignancy assessment. |
| Publish Date |
2019-09-28 10:12 |
| Citation |
Laquière AE, Lagarde A, Napoléon B, Bourdariat R, Atkinson A, Donatelli G, Pol B, Lecomte L, Curel L, Urena-Campos R, Helbert T, Valantin V, Mithieux F, Buono JP, Grandval P, Olschwang S. Genomic profile concordance between pancreatic cyst fluid and neoplastic tissue. World J Gastroenterol 2019; 25(36): 5530-5542 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i36/5530.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i36.5530 |
