Publication Name	World Journal of Gastroenterology
Manuscript ID	4815
Country	China

Received	2013-07-25 09:51
Peer-Review Started	2013-07-25 15:02
First Decision by Editorial Office Director
Return for Revision	2013-08-23 09:39
Revised
Publication Fee Transferred
Second Decision by Editor	2013-09-29 10:21
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-09-29 22:12
Articles in Press
Edit the Manuscript by Language Editor	2013-10-15 14:20
Typeset the Manuscript	2013-11-14 12:18
Publish the Manuscript Online	2013-12-18 09:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	Insulin-like growth factor-1 induces lymphangiogenesis and facilitates lymphatic metastasis in colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Zhen-Jun Li, Xiao-Jiang Ying, Hong-Liang Chen, Ping-Jiang Ye, Zhi-Liang Chen, Gang Li, Hua-Feng Jiang, Jiang Liu and Shu-Zhen Zhou
Funding Agency and Grant Number	Funding Agency Grant Number Technological Research Project for Public Welfare from Science and Technology Department of Zhejiang Province, China 2010C33099
Corresponding Author	Xiao-Jiang Ying, MD, Department of Colorectal Surgery, Shaoxing People’s Hospital, Shaoxing Hospital of Zhejiang University, No. 568, Zhongxing North Street, Shaoxing 312000, Zhejiang Province, China. lzdx2003@163.com
Key Words	Colorectal cancer; Insulin-like growth factor-1; Insulin-like growth factor-1 receptor; Lymphangiogenesis; Lymphatic metastasis
Core Tip	Insulin-like growth factor-1 (IGF-1) and its receptor, insulin-like growth factor-1 receptor (IGF-1R), are frequently overexpressed in many types of tumors including colorectal cancer. A recent study (Bj?rndahl et al, 2003) showed that both IGF-1 and IGF-2 could potently stimulate lymphatic vessel growth in the mouse cornea. However, equivalent evidence on IGF-1 in solid tumors is lacking. Here, we show that IGF-1/IGF-1R signaling induces tumor-associated lymphangiogenesis in vivo and contributes to lymphatic metastasis of colorectal cancer. Findings from the present study provide further evidence to support the involvement of IGF-1/IGF-1R signaling in lymphangiogenesis in solid tumors.
Publish Date	2013-12-18 09:53
Citation	Li ZJ, Ying XJ, Chen HL, Ye PJ, Chen ZL, Li G, Jiang HF, Liu J, Zhou SZ. Insulin-like growth factor-1 induces lymphangiogenesis and facilitates lymphatic metastasis in colorectal cancer. World J Gastroenterol 2013; 19(43): 7788-7794
URL	http://www.wjgnet.com/1007-9327/full/v19/i43/7788.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i43.7788

Full Article (PDF)	WJG-19-7788.pdf
Manuscript File	4815-review.doc
Answering Reviewers	4815-Answering Reviewers.pdf
Copyright License Agreement	4815-Copyright Assignment.pdf
Non-Native Speakers of English Editing Certificate	4815-Language certificate.pdf
Peer-review Report	4815-Peer Review(s).pdf
Scientific Editor Work List	4815-Scientific editor work list.doc