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Articles Published Processes
7/14/2019 11:25:18 AM | Browse: 935 | Download: 1692
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Received |
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2019-04-12 07:29 |
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Peer-Review Started |
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2019-04-12 10:27 |
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To Make the First Decision |
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2019-05-14 01:08 |
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Return for Revision |
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2019-05-15 02:13 |
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Revised |
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2019-05-18 01:18 |
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Second Decision |
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2019-05-30 08:36 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-06-01 13:03 |
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Articles in Press |
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2019-06-01 13:03 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-06-14 00:07 |
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Typeset the Manuscript |
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2019-07-13 11:37 |
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Publish the Manuscript Online |
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2019-07-14 11:25 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Raddeanin A promotes apoptosis and ameliorates 5-fluorouracil-resistance in the cholangiocarcinoma cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shuang-Shuang Guo, Ying Wang and Qing-Xia Fan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Qing-Xia Fan, MD, PhD, Doctor, Doctor, Department of Oncology, the First Affiliated Hospital of Zhengzhou University, 1 Jianshe E Rd, Erqi District, Zhengzhou 450052, Henan Province, China. huinaochangtu81@163.com |
| Key Words |
Bile duct cancer; Raddeanin A; 5-fluorouracil; Cell cycle; Apoptosis |
| Core Tip |
We report that raddeanin A (RA) reduced cell viability, migration and colony formation ability in cholangiocarcinoma cells and RA enhanced the antitumor effect of 5-Fu in cholangiocarcinoma cells. This study also demonstrated that anticancer effects of RA were associated with apoptosis-related protein Bax and B cell lymphoma 2 and that anticancer effects of RA were involved in cell cycle-related protein weel, cyclin D1, cyclin E, and cyclooxygenase-2. |
| Publish Date |
2019-07-14 11:25 |
| Citation |
Guo SS, Wang Y, Fan QX. Raddeanin A promotes apoptosis and ameliorates 5-fluorouracil-resistance in the cholangiocarcinoma cells. World J Gastroenterol 2019; 25(26): 3380-3391 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i26/3380.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i26.3380 |
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