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Articles Published Processes
8/26/2019 2:56:47 AM | Browse: 684 | Download: 1055
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Received |
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2019-04-25 03:30 |
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Peer-Review Started |
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2019-05-07 01:08 |
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To Make the First Decision |
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2019-06-03 03:13 |
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Return for Revision |
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2019-06-17 01:31 |
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Revised |
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2019-06-23 06:09 |
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Second Decision |
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2019-07-26 09:13 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-07-27 21:55 |
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Articles in Press |
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2019-07-27 21:55 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-08-10 18:59 |
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Typeset the Manuscript |
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2019-08-21 07:27 |
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Publish the Manuscript Online |
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2019-08-26 02:56 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Observational Study |
| Article Title |
TAZ and myostatin involved in muscle atrophy of congenital neurogenic clubfoot
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jia-Xing Sun, Ze-Yu Yang, Li-Mei Xie, Bing Wang, Ning Bai and Ai-Lu Cai |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ai-Lu Cai, MD, PhD, Professor, Department of Ultrasound, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang 110004, Liaoning Province, China. caial1224@sina.com |
| Key Words |
Congenital clubfoot; Neurogenic; Muscle atrophy; Myostatin; TAZ; |
| Core Tip |
This study aimed to identify muscle atrophy in fetal neurogenic clubfoot; detect expression of TAZ and myostatin in gastrocnemius muscle; and establish the mechanisms through which TAZ antagonizes myostatin-induced atrophy in an in vitro cell model. Muscle atrophy in fetal unilateral clubfoot with nervous system abnormalities was identified by ultrasound. TAZ overexpression in C2C12 myotubes induced atrophy by myostatin. Both TAZ and myostatin are involved in the process of neurogenic clubfoot muscle atrophy, and they are negatively correlated. TAZ antagonizes myostatin-induced myotube atrophy, potentially through regulation of the Akt/FOXO4 pathway. |
| Publish Date |
2019-08-26 02:56 |
| Citation |
Sun JX, Yang ZY, Xie LM, Wang B, Bai N, Cai AL. TAZ and myostatin involved in muscle atrophy of congenital neurogenic clubfoot. World J Clin Cases 2019; 7(16): 2238-2246 |
| URL |
https://www.wjgnet.com/2307-8960/full/v7/i16/ 2238.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v7.i16.2238 |
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