Publication Name	World Journal of Gastroenterology
Manuscript ID	4853
Country	Australia

Received	2013-07-28 06:33
Peer-Review Started	2013-07-29 17:24
First Decision by Editorial Office Director
Return for Revision	2013-08-22 19:29
Revised
Publication Fee Transferred
Second Decision by Editor	2013-09-29 10:06
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-09-29 21:44
Articles in Press
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-10-29 20:40
Publish the Manuscript Online	2013-11-16 18:29

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Interaction of IFNL3 with insulin resistance, steatosis and lipid metabolism in chronic hepatitis C virus infection
Manuscript Source	Invited Manuscript
All Author List	Mohammed Eslam, David R Booth, Jacob George and Golo Ahlenstiel
Funding Agency and Grant Number	Funding Agency Grant Number National Health and Medical Research Council Project APP1006759 Robert W. Storr bequest to the Sydney Medical Foundation of the University of Sydney to Ahlenstiel G and George J International Postgraduate Research Scholarships to Eslam M Australian Postgraduate Award of the University of Sydney to Eslam M
Corresponding Author	Dr. Golo Ahlenstiel, Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney, Sydney, NSW 2145, Australia. golo.ahlenstiel@sydney.edu.au
Key Words	IFNL3; Chronic hepatitis C; Insulin resistance; Lipids
Core Tip	Metabolic changes are inextricably linked to chronic hepatitis C (CHC). Recently polymorphisms in the IFNL3 region have been shown to be strongly associated with spontaneous and treatment induced recovery from hepatitis C virus (HCV) infection. Further, circumstantial evidence suggests a link between IFNL3 single nucleotide polymorphisms and lipid metabolism, steatosis and insulin resistance in CHC. The emerging picture suggests that the responder genotypes of IFNL3 polymorphisms are associated with a higher serum lipid profile, and less frequent steatosis and insulin resistance. This review analyzes the current data regarding this interaction and its meaning for HCV pathogenesis and disease progression.
Publish Date	2013-11-16 18:29
Citation	Eslam M, Booth DR, George J, Ahlenstiel G. Interaction of IFNL3 with insulin resistance, steatosis and lipid metabolism in chronic hepatitis C virus infection. World J Gastroenterol 2013; 19(41): 7055-7061
URL	http://www.wjgnet.com/1007-9327/full/v19/i41/7055.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i41.7055

Full Article (PDF)	WJG-19-7055.pdf
Manuscript File	4853-Review.docx
Answering Reviewers	4853-Answering reviewers.pdf
Biostatistics Review Certificate	Biostatistician_Review_Report_20130727165057.pdf
Copyright License Agreement	4853-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20130727164909.pdf
Peer-review Report	4853-Peer review(s).pdf
Scientific Editor Work List	4853-Scientific editor work list.doc