Publication Name	World Journal of Gastroenterology
Manuscript ID	48751
Country	Switzerland

Received	2019-05-02 05:32
Peer-Review Started	2019-05-04 09:07
To Make the First Decision	2019-05-27 00:36
Return for Revision	2019-05-31 01:33
Revised	2019-06-25 08:44
Second Decision	2019-07-19 09:14
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2019-07-19 15:39
Articles in Press	2019-07-19 15:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-08-28 06:16
Publish the Manuscript Online	2019-08-28 12:23

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Review of current diagnostic methods and advances in Helicobacter pylori diagnostics in the era of next generation sequencing
Manuscript Source	Invited Manuscript
All Author List	Daniel Pohl, Peter M Keller, Valentine Bordier and Karoline Wagner
ORCID	Author(s) ORCID Number Daniel Pohl http://orcid.org/0000-0002-0855-1152 Peter M Keller http://orcid.org/0000-0002-2890-5384 Valentine Bordier http://orcid.org/0000-0002-1229-825X Karoline Wagner http://orcid.org/0000-0002-4761-1285
Funding Agency and Grant Number
Corresponding Author	Karoline Wagner, PhD, Postdoc, Division of Laboratory Medicine, University Hospital of Basel, Petersgraben 4, Basel 4031, Switzerland. karoline.wagner@usb.ch
Key Words	Helicobacter pylori; Advances in diagnostics; Next generation sequencing; Whole genome sequencing; Clinical management;
Core Tip	With worldwide increasing antibiotic resistance in Helicobacter pylori (H. pylori), drug resistance phenotypes should be determined prior to the administration of antibiotic eradication regimens. Our literature search yielded studies that focused on the prediction of drug resistance phenotypes in H. pylori based on the presence of certain point mutations in the bacterium’s genome using next generation sequencing (NGS) technology. Thus, NGS technology may enable the implementation of rapid and accurate genotypic drug susceptibility testing prior to the administration of antimicrobial therapy. This may increase H. pylori eradication rates and ultimately improve patient management.
Publish Date	2019-08-28 12:23
Citation	Pohl D, Keller PM, Bordier V, Wagner K. Review of current diagnostic methods and advances in Helicobacter pylori diagnostics in the era of next generation sequencing. World J Gastroenterol 2019; 25(32): 4629-4660
URL	https://www.wjgnet.com/1007-9327/full/v25/i32/4629.htm
DOI	https://dx.doi.org/10.3748/wjg.v25.i32.4629

Full Article (PDF)	WJG-25-4629.pdf
Full Article (Word)	WJG-25-4629.docx
Manuscript File	48751-Review.docx
Answering Reviewers	48751-Answering reviewers.pdf
Audio Core Tip	48751-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	48751-Conflict-of-interest statement.pdf
Copyright License Agreement	48751-Copyright license agreement.pdf
Peer-review Report	48751-Peer-review(s).pdf
Scientific Misconduct Check	48751-Scientific misconduct check.pdf
Scientific Editor Work List	48751-Scientific editor work list.pdf
CrossCheck Report	48751-CrossCheck Report.pdf