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Articles Published Processes
10/14/2019 10:47:07 AM | Browse: 802 | Download: 1289
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Received |
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2019-05-05 01:39 |
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Peer-Review Started |
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2019-05-05 07:58 |
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To Make the First Decision |
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2019-06-10 08:23 |
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Return for Revision |
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2019-06-14 00:34 |
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Revised |
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2019-07-26 22:48 |
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Second Decision |
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2019-08-30 11:49 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-09-28 04:50 |
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Articles in Press |
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2019-09-28 04:50 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-10-14 07:44 |
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Publish the Manuscript Online |
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2019-10-14 10:47 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Role of ion channels in gastrointestinal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Kyle J Anderson, Robert T Cormier and Patricia M Scott |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Patricia M Scott, PhD, Assistant Professor, Department of Biomedical Sciences, University of Minnesota Medical School, 1035 University Drive, Duluth, MN 55812, United States. pscott@d.umn.edu |
| Key Words |
Ion channels; Gastrointestinal cancer; Colorectal cancer; Gastric cancer; Pancreatic cancer; Esophageal cancer |
| Core Tip |
Ion channels play an essential function in the physiology of the GI tract. There is increasing evidence that they are dysregulated at all stages of gastrointestinal (GI) cancer, from early initiation to metastasis. This information provides for the use of ion channel expression as useful clinical prognostic biomarkers in GI cancer. Perhaps more importantly new therapeutic modalities targeting ion channels in the GI tract, including the potential to target their dysregulation in GI cancers are becoming increasingly feasible. This strategy includes the repurposing of existing drugs that are used to treat other ion channel pathologies, or other diseases altogether. This review seeks to provide an overview of the role of ion channels in GI cancers with an emphasis on the potential for new therapies that target them. |
| Publish Date |
2019-10-14 10:47 |
| Citation |
Anderson KJ, Cormier RT, Scott PM. Role of ion channels in gastrointestinal cancer. World J Gastroenterol 2019; 25(38): 5732-5772 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i38/5732.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i38.5732 |
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