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10/14/2019 10:47:07 AM | Browse: 116 | Download: 139
Publication Name World Journal of Gastroenterology
Manuscript ID 48781
Country/Territory United States
2019-05-05 01:39
Peer-Review Started
2019-05-05 07:58
To Make the First Decision
2019-06-10 08:23
Return for Revision
2019-06-14 00:34
2019-07-26 22:48
Second Decision
2019-08-30 11:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-09-28 04:50
Articles in Press
2019-09-28 04:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-10-14 07:44
Publish the Manuscript Online
2019-10-14 10:47
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Role of ion channels in gastrointestinal cancer
Manuscript Source Unsolicited Manuscript
All Author List Kyle J Anderson, Robert T Cormier and Patricia M Scott
Author(s) ORCID Number
Kyle J Anderson http://orcid.org/0000-0001-7144-0992
Robert T Cormier http://orcid.org/0000-0003-4423-7053
Patricia M Scott http://orcid.org/0000-0002-6336-2653
Funding Agency and Grant Number
Corresponding author Patricia M Scott, PhD, Assistant Professor, Department of Biomedical Sciences, University of Minnesota Medical School, 1035 University Drive, Duluth, MN55812, United States. pscott@d.umn.edu
Keywords Ion channels; Gastrointestinal cancer; Colorectal cancer; Gastric cancer; Pancreatic cancer; Esophageal cancer
Core Tip Ion channels play an essential function in the physiology of the GI tract. There is increasing evidence that they are dysregulated at all stages of gastrointestinal (GI) cancer, from early initiation to metastasis. This information provides for the use of ion channel expression as useful clinical prognostic biomarkers in GI cancer. Perhaps more importantly new therapeutic modalities targeting ion channels in the GI tract, including the potential to target their dysregulation in GI cancers are becoming increasingly feasible. This strategy includes the repurposing of existing drugs that are used to treat other ion channel pathologies, or other diseases altogether. This review seeks to provide an overview of the role of ion channels in GI cancers with an emphasis on the potential for new therapies that target them.
Publish Date 2019-10-14 10:47
Citation Anderson KJ, Cormier RT, Scott PM. Role of ion channels in gastrointestinal cancer. World J Gastroenterol 2019; 25(38): 5732-5772
Url https://www.wjgnet.com/1007-9327/full/v25/i38/5732.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i38.5732
Full Article (PDF) WJG-25-5732.pdf
Full Article (Word) WJG-25-5732.docx
Manuscript File 48781-Review.docx
Answering Reviewers 48781-Answering reviewers.pdf
Audio Core Tip 48781-Audio core tip.aif
Conflict-of-Interest Disclosure Form 48781-Conflict-of-interest statement.pdf
Copyright License Agreement 48781-Copyright license agreement.pdf
Peer-review Report 48781-Peer-review(s).pdf
Scientific Misconduct Check 48781-Scientific misconduct check.pdf
Scientific Editor Work List 48781-Scientific editor work list.pdf