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Articles Published Processes
12/10/2019 2:02:23 AM | Browse: 1407 | Download: 2498
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Received |
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2019-05-05 02:39 |
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Peer-Review Started |
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2019-05-08 02:58 |
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First Decision by Editorial Office Director |
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2019-07-31 19:04 |
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Return for Revision |
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2019-08-27 03:51 |
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Revised |
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2019-09-09 18:16 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2019-10-14 09:05 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2019-10-14 16:47 |
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Articles in Press |
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2019-10-14 16:47 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-11-15 10:26 |
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Publish the Manuscript Online |
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2019-12-10 02:02 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Case Control Study |
| Article Title |
Relationship between cachexia and perineural invasion in pancreatic adenocarcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Livia Petrusel, Ioana Rusu, Daniel Corneliu Leucuta, Radu Seicean, Ramona Suharoschi, Paula Zamfir and Andrada Seicean |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Livia Petrusel, MD, PhD, Doctor, Doctor, Institute of Gastroenterology and Hepatology, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Croitorilor 19-21, Cluj-Napoca 400162, Romania. livia.cutas@umfcluj.ro |
| Key Words |
Pancreatic adenocarcinoma; Cachexia; Perineural invasion; Activin; Midkine; Biomarker |
| Core Tip |
Midkine (MK) is a neurotrophic factor that promotes perineural invasion in pancreatic cancer, neuronal differentiation and cell migration. Our results confirmed that high MK expression is closely correlated with perineural invasion and with advanced tumor stage, diabetes. No relationship with cachexia was found. Activin plays a dominant role in the development and progression of cachexia and in tumor cell growth in pancreatic adenocarcinoma, but this was not confirmed in this study, despite the association with poor survival. |
| Publish Date |
2019-12-10 02:02 |
| Citation |
Petrusel L, Rusu I, Leucuta DC, Seicean R, Suharoschi R, Zamfir P, Seicean A. Relationship between cachexia and perineural invasion in pancreatic adenocarcinoma. World J Gastrointest Oncol 2019; 11(12): 1126-1140
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| URL |
https://www.wjgnet.com/1948-5204/full/v11/i12/1126.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v11.i12.1126 |
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