| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Melissa Frizziero, Xin Wang, Bipasha Chakrabarty, Alexa Childs, Tu Vinh Luong, Thomas Walter, Mohid S. Khan, Meleri Morgan, Adam Christian, Mona Elshafie, Tahir Shah, Annamaria Minicozzi, Wasat Mansoor, Tim Meyer, Angela Lamarca, Richard A Hubner, Juan W Valle and Mairéad G McNamara |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mairéad G McNamara, BM BCh, MD, MSc, PhD, Attending Doctor, Doctor, Doctor, Senior Lecturer, Senior Researcher, Department of Medical Oncology;Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong higher Education Institutes, The Christie NHS Foundation Trust, 550 Wilmslow Road, Manchester M20 4BX, United Kingdom. mairead.mcnamara@christie.nhs.uk |
| Key Words |
Mixed neuroendocrine non-neuroendocrine neoplasm; 2017 World Health Organisation classification; Mixed adeno-neuroendocrine carcinoma; Gastro-entero-pancreatic tract; Digestive system; Neuroendocrine neoplasms |
| Core Tip |
Mixed neuroendocrine non-neuroendocrine neoplasm (MiNEN) is a rare, albeit aggressive diagnosis. Evidence from literature is limited and inconsistent. This study reports on one of the largest cohorts of patients with a diagnosis of MiNEN in the current literature, and aims to provide useful suggestions for clinical management, in the absence of data from clinical trials. Potentially curable cases are most commonly offered surgery alone or in combination with chemotherapy or chemo-radiotherapy (predominantly according to the ‘standard of care’ for adenocarcinomas). Advanced cases are most often treated with palliative chemotherapy and protocols follow either the ‘standard of care’ for adenocarcinomas or neuroendocrine carcinomas. |
| Publish Date |
2019-10-21 09:37 |
| Citation |
Frizziero M, Wang X, Chakrabarty B, Childs A, Luong TV, Walter T, Khan MS, Morgan M, Christian A, Elshafie M, Shah T, Minicozzi A, Mansoor W, Meyer T, Lamarca A, Hubner RA, Valle JW, McNamara MG. Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres. World J Gastroenterol 2019; 25(39): 5991-6005 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i39/5991.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i39.5991 |
