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Articles Published Processes
10/25/2019 8:04:09 AM | Browse: 1001 | Download: 2076
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Received |
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2019-05-22 01:21 |
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Peer-Review Started |
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2019-05-23 11:22 |
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First Decision by Editorial Office Director |
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2019-08-02 03:12 |
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Return for Revision |
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2019-08-06 05:08 |
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Revised |
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2019-08-29 14:13 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2019-10-18 08:10 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2019-10-18 23:08 |
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Articles in Press |
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2019-10-18 23:08 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-10-25 03:31 |
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Publish the Manuscript Online |
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2019-10-25 08:04 |
| ISSN |
2220-6124 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Urology & Nephrology |
| Manuscript Type |
Case Control Study |
| Article Title |
Complement activation and long-term graft function in ABO-incompatible kidney transplantation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Marit S van Sandwijk, Astrid Klooster, Ineke JM ten Berge, Arjan Diepstra, Sandrine Florquin, Joris J Hoelbeek, Frederike J Bemelman and Jan-Stephan Sanders |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Marit S van Sandwijk, MD, Staff Physician, Department of Nephrology, Amsterdam University Medical Centers, location AMC, Meibergdreef 9, Amsterdam NL-1105 AZ, Netherlands. m.s.vansandwijk@amsterdamumc.nl |
| Key Words |
ABO-incompatible; Kidney transplantation; Complement; Graft function; Rejection; |
| Core Tip |
This retrospective case-control study was designed to unravel the relationship between complement activation, pre-transplant anti-ABO antibodies, and renal graft function. In this study, the slope of kidney function during a five-year follow up was not significantly different compared to matched ABO-compatible transplant recipients, but ABO-incompatible kidney transplant recipients did have a lower kidney function at three months, due to a high rate of early T-cell mediated rejection. Based on several complement staining results, we argue that this may be due to co-stimulation of T-cell activation by ongoing complement activation by anti-ABO antibodies. |
| Publish Date |
2019-10-25 08:04 |
| Citation |
van Sandwijk MS, Klooster A, ten Berge IJM, Diepstra A, Florquin S, Hoelbeek JJ, Bemelman FJ, Sanders JS. Complement activation and long-term graft function in ABO-incompatible kidney transplantation. World J Nephrol 2019; 8(6): 95-108 |
| URL |
https://www.wjgnet.com/2220-6124/full/v8/i6/95.htm |
| DOI |
https://dx.doi.org/10.5527/wjn.v8.i6.95 |
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