Publication Name	World Journal of Gastroenterology
Manuscript ID	4896
Country	China

Received	2013-07-31 10:42
Peer-Review Started	2013-07-31 23:26
To Make the First Decision	2013-08-21 18:52
Return for Revision	2013-08-30 11:01
Revised	2013-09-07 00:00
Second Decision	2013-11-04 18:05
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-05 10:33
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-11-19 11:15
Typeset the Manuscript	2013-12-10 12:10
Publish the Manuscript Online	2014-01-20 16:41

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Autobiography
Article Title	Separate calculation of DW-MRI in assessing therapeutic effect in liver tumors in rats
Manuscript Source	Invited Manuscript
All Author List	Feng Chen, Frederik De Keyzer, Yuan-Bo Feng, Marlein Miranda Cona, Jie Yu, Guy Marchal, Raymond Oyen and Yi-Cheng Ni
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 30670603
Corresponding Author	Feng Chen, MD, PhD, Deputy Director, Department of Radiology, the First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. chenfengbe@aliyun.com
Key Words	Diffusion weighted imaging; Magnetic resonance imaging; Therapeutic assessment; Liver tumor; Rats; Vascular disrupting agent; Antiangiogenic agent; Animal model; Rodents
Core Tip	The combination therapy with ZD6126 and thalidomide significantly delayed liver tumor growth due to synergistic effects by inducing cumulative tumor necrosis in rodents. The apparent diffusion coefficient (ADC)high performed significantly better than ADCall for the monitoring of tumor necrosis on day 2. The ADCperf could better reflect the reduction of blood flow due to the vessel shutdown induced by ZD6126, compared to the ADClow. The ADCperf could provide valuable perfusion information from diffusion weighted magnetic resonance imaging data.
Publish Date	2014-01-20 16:41
Citation	Chen F, Keyzer FD, Feng YB, Cona MM, Yu J, Marchal G, Oyen R, Ni YC. Separate calculation of DW-MRI in assessing therapeutic effect in liver tumors in rats. World J Gastroenterol 2013; 19(47): 9092-9103
URL	http://www.wjgnet.com/1007-9327/full/v19/i47/9092.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i47.9092

Full Article (PDF)	WJG-19-9092.pdf
Manuscript File	4896-Review.doc
Answering Reviewers	4896-Answering reviewers.pdf
Copyright License Agreement	4896-Copyright assignment.pdf
Peer-review Report	4896-Peer reviewer(s).pdf
Scientific Editor Work List	4896-Scientific editor work list.doc