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12/18/2019 7:15:58 AM | Browse: 763 | Download: 1277
Publication Name World Journal of Experimental Medicine
Manuscript ID 48984
Country/Territory Japan
Received
2019-05-17 08:04
Peer-Review Started
2019-05-20 01:42
To Make the First Decision
2019-08-06 01:20
Return for Revision
2019-08-06 05:43
Revised
2019-09-05 02:32
Second Decision
2019-11-19 01:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-11-21 20:18
Articles in Press
2019-11-21 20:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-12-02 02:41
Typeset the Manuscript
2019-12-16 01:11
Publish the Manuscript Online
2019-12-18 07:15
ISSN 2220-315x (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research & Experimental
Manuscript Type Basic Study
Article Title Localization of ATP-sensitive K+ channel subunits in rat liver
Manuscript Source Invited Manuscript
All Author List Ming Zhou, Kiwamu Yoshikawa, Hideo Akashi, Mitsutaka Miura, Ryoji Suzuki, Tao-Sheng Li, Hiroshi Abe and Yoshio Bando
ORCID
Author(s) ORCID Number
Ming Zhou http://orcid.org/0000-0001-8775-9738
Kiwamu Yoshikawa http://orcid.org/0000-0002-0053-6492
Hideo Akashi http://orcid.org/0000-0001-8520-0252
Mitsutaka Miura http://orcid.org/0000-0001-8454-8978
Ryoji Suzuki http://orcid.org/0000-0003-4526-7406
Tao-Sheng Li http://orcid.org/0000-0002-7653-8873
Hiroshi Abe http://orcid.org/0000-0002-4683-4487
Yoshio Bando http://orcid.org/0000-0002-2466-5248
Funding Agency and Grant Number
Funding Agency Grant Number
Program of the network-type joint Usage/Research Center for Radiation Disaster Medical Science of Hiroshima University, Nagasaki University and Fukushima Medical University
Corresponding Author Ming Zhou, MD, PhD, Assistant Professor, Department of Anatomy, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan. mzhou@med.akita-u.ac.jp
Key Words ATP-sensitive K+ channel; Liver; Hepatic stellate cells; Kupffer cells; Sinusoidal endothelial cells; Rat
Core Tip ATP-sensitive K+ (KATP) channels have been found ubiquitously distributed in a variety of cell types and tissues, but the present study revealed that five kinds of KATP channel subunit expressed in rat liver by western blot analysis, immunohistochemistry, and immunocytochemistry in rat liver tissue and primary cultured cells. These KATP channel subunits were not only localized in hepatocytes but also in sinusoidal cells such as hepatic stellate cells (HSCs), Kupffer cells, and sinusoidal endothelial cells, which were proofed by special marker labelling such as GFAP for HSCs, CD68 for Kupffer cells, and SE-1 for sinusoidal endothelial cells. The wide and diversity of KATP channel subunit compositions in rat liver might correspond to their various functions in hepatocytes and sinusoidal cells.
Publish Date 2019-12-18 07:15
Citation Zhou M, Yoshikawa K, Akashi H, Miura M, Suzuki R, Li TS, Abe H, Bando Y. Localization of ATP-sensitive K+ channel subunits in rat liver. World J Exp Med 2019; 2019; 9(2): 14-31
URL https://www.wjgnet.com/2220-315X/full/v9/i2/14.htm
DOI https://dx.doi.org/10.5493/wjem.v9.i2.14
Full Article (PDF) WJEM-9-14.pdf
Full Article (Word) WJEM-9-14.docx
The ARRIVE Guidelines 48984-The-ARRIVE-Guidelines-revision.pdf
Manuscript File 48984-Review-Filipodia.doc
Answering Reviewers 48984-Answering reviewers.pdf
Audio Core Tip 48984-Audio core tip.mp3
Biostatistics Review Certificate 48984-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 48984-Conflict-of-interest statement.pdf
Copyright License Agreement 48984-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 48984-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 48984-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 48984-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 48984-Language certificate.pdf
Peer-review Report 48984-Peer-review(s).pdf
Scientific Misconduct Check 48984-Scientific misconduct check.pdf
Scientific Editor Work List 48984-Scientific editor work list.pdf