ISSN |
2220-315x (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Medicine, Research & Experimental |
Manuscript Type |
Basic Study |
Article Title |
Localization of ATP-sensitive K+ channel subunits in rat liver
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Manuscript Source |
Invited Manuscript |
All Author List |
Ming Zhou, Kiwamu Yoshikawa, Hideo Akashi, Mitsutaka Miura, Ryoji Suzuki, Tao-Sheng Li, Hiroshi Abe and Yoshio Bando |
ORCID |
|
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Program of the network-type joint Usage/Research Center for Radiation Disaster Medical Science of Hiroshima University, Nagasaki University and Fukushima Medical University |
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Corresponding Author |
Ming Zhou, MD, PhD, Assistant Professor, Department of Anatomy, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan. mzhou@med.akita-u.ac.jp |
Key Words |
ATP-sensitive K+ channel; Liver; Hepatic stellate cells; Kupffer cells; Sinusoidal endothelial cells; Rat |
Core Tip |
ATP-sensitive K+ (KATP) channels have been found ubiquitously distributed in a variety of cell types and tissues, but the present study revealed that five kinds of KATP channel subunit expressed in rat liver by western blot analysis, immunohistochemistry, and immunocytochemistry in rat liver tissue and primary cultured cells. These KATP channel subunits were not only localized in hepatocytes but also in sinusoidal cells such as hepatic stellate cells (HSCs), Kupffer cells, and sinusoidal endothelial cells, which were proofed by special marker labelling such as GFAP for HSCs, CD68 for Kupffer cells, and SE-1 for sinusoidal endothelial cells. The wide and diversity of KATP channel subunit compositions in rat liver might correspond to their various functions in hepatocytes and sinusoidal cells. |
Publish Date |
2019-12-18 07:15 |
Citation |
Zhou M, Yoshikawa K, Akashi H, Miura M, Suzuki R, Li TS, Abe H, Bando Y. Localization of ATP-sensitive K+ channel subunits in rat liver. World J Exp Med 2019; 2019; 9(2): 14-31 |
URL |
https://www.wjgnet.com/2220-315X/full/v9/i2/14.htm |
DOI |
https://dx.doi.org/10.5493/wjem.v9.i2.14 |