Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	49163
Country	United States

Received	2019-05-16 00:14
Peer-Review Started	2019-05-20 01:16
To Make the First Decision	2019-06-03 02:33
Return for Revision	2019-06-12 00:39
Revised	2019-06-25 12:15
Second Decision	2019-07-25 00:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2019-07-25 18:42
Articles in Press	2019-07-25 18:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-07-26 09:29
Publish the Manuscript Online	2019-07-27 06:37

ISSN	1948-9366 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Editorial
Article Title	Optimizing neoadjuvant radiotherapy for resectable and borderline resectable pancreatic cancer using protons
Manuscript Source	Invited Manuscript
All Author List	Romaine Charles Nichols and Michael S Rutenberg
ORCID	Author(s) ORCID Number Romaine Charles Nichols http://orcid.org/0000-0003-2171-7791 Michael S Rutenberg http://orcid.org/0000-0001-6945-7883
Funding Agency and Grant Number
Corresponding Author	Romaine Charles Nichols, MD, Associate Professor, Department of Radiation Oncology, University of Florida College of Medicine, 015 North Jefferson Street, Jacksonville, FL 32206, United States. rnichols@floridaproton.org
Key Words	Radiation oncology; Pancreatic cancer; Proton therapy; ; ;
Core Tip	Patients with resectable and borderline resectable pancreatic cancer are at a high risk of suffering postoperative local-regional failure. Preoperative radiotherapy directed to gross disease and regional lymphatic beds at high risk of harboring microscopic disease appears to be an oncologically rational intervention to reduce this risk. When proton-based radiotherapy addressing gross disease as well as high-risk regional lymphatic beds is delivered prior to surgery, it does not appear to increase the risk of surgical complications or the duration of surgery. Because of this, we would argue that proton-based preoperative radiotherapy should be considered for patients with resectable and borderline resectable disease.
Publish Date	2019-07-27 06:37
Citation	Nichols RC, Rutenberg M. Optimizing neoadjuvant radiotherapy for resectable and borderline resectable pancreatic cancer using protons. World J Gastrointest Surg 2019; 11(7): 303-307
URL	https://www.wjgnet.com/1948-9366/full/v11/i7/303.htm
DOI	https://dx.doi.org/10.4240/wjgs.v11.i7.303

Full Article (PDF)	WJGS-11-303.pdf
Full Article (Word)	WJGS-11-303.docx
Manuscript File	49163-Review.docx
Answering Reviewers	49163-Answering reviewers.pdf
Audio Core Tip	49163-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	49163-Conflict-of-interest statement.pdf
Copyright License Agreement	49163-Copyright license agreement.pdf
Peer-review Report	49163-Peer-review(s).pdf
Scientific Misconduct Check	49163-Scientific misconduct check.pdf
Scientific Editor Work List	49163-Scientific editor work list.pdf
CrossCheck Report	49163-CrossCheck report.pdf