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Articles Published Processes
2/27/2020 7:06:19 AM | Browse: 605 | Download: 871
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Received |
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2019-05-18 05:29 |
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Peer-Review Started |
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2019-05-20 02:10 |
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To Make the First Decision |
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2019-08-28 05:24 |
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Return for Revision |
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2019-09-02 09:11 |
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Revised |
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2019-10-19 13:25 |
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Second Decision |
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2020-01-11 09:23 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-01-15 00:10 |
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Articles in Press |
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2020-01-15 00:10 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-02-03 05:54 |
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Typeset the Manuscript |
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2020-02-25 01:50 |
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Publish the Manuscript Online |
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2020-02-27 07:06 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Minireviews |
| Article Title |
Cartilage and bone tissue engineering using adipose stromal/stem cells spheroids as building blocks
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Gabriela S Kronemberger, Renata Akemi Morais Matsui, Guilherme de Almeida Santos de Castro e Miranda, José Mauro Granjeiro and Leandra Santos Baptista |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Coordination for the Improvement of Higher Education Personnel (CAPES) |
88882.366181/2019-01 |
| Carlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro (FAPERJ) |
E-26/202.682/2018 |
| National Council for Scientific and Technological Development (CNPq) |
467513/2014-7 |
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| Corresponding Author |
Leandra Santos Baptista, PhD, Academic Research, Associate Professor, Laboratory of Tissue Bioengineering, Directory of Metrology Applied to Life Sciences, National Institute of Metrology, Quality and Technology (INMETRO), Duque de Caxias 25245-390, RJ, Brazil. leandra.baptista@gmail.com |
| Key Words |
Adipose stromal/stem cells; Spheroids; Building-blocks; Bottom-up; Developmental tissue engineering; Cartilage and bone |
| Core Tip |
Classic approaches to tissue engineering rely on scaffold-based strategies, which have limited ability to recapitulate organogenesis in vitro and are not capable of generating hierarchical engineered tissues. Scaffold-free strategies, in particular those using spheroids, are appealing, mainly due the capacity of spheroids to recapitulate three main embryonic process: (1) cell-to-cell and cell-to-extracellular matrix interactions; (2) cell differentiation; and (3) fusion. The use of spheroids to recapitulate embryonic tissue formation in vitro represent a potent strategy in developmental tissue engineering. In particular, the fusion capacity of spheroids allows their use as building-blocks in bottom-up tissue engineering trough three-dimensional bioprinting techniques. |
| Publish Date |
2020-02-27 07:06 |
| Citation |
Kronemberger GS, Matsui RAM, Miranda GASC, Granjeiro JM, Baptista LS. Cartilage and bone tissue engineering using adipose stromal/stem cells spheroids as building blocks. World J Stem Cells 2020; 12(2): 110-122 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i2/110.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i2.110 |
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