Publication Name	World Journal of Diabetes
Manuscript ID	4939
Country	United States

Received	2013-08-02 11:24
Peer-Review Started	2013-08-02 21:57
To Make the First Decision	2013-08-08 11:16
Return for Revision	2013-08-19 18:24
Revised	2013-08-22 00:59
Second Decision	2013-10-16 11:20
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-10-16 12:25
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-12-06 09:24
Publish the Manuscript Online	2013-12-20 16:49

ISSN	1948-9358 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Field of Vision
Article Title	Betatrophin: A liver-derived hormone for the pancreatic -cell proliferation
Manuscript Source	Invited Manuscript
All Author List	Rajendra Raghow
Funding Agency and Grant Number
Corresponding Author	Rajendra Raghow, PhD, Professor, Department of Veterans Affairs Medical Center, 1030 Jefferson Avenue, Memphis, TN 38104, United States. rraghow@uthsc.edu
Key Words	Type 2 diabetes mellitus; Insulin resistance; Liver-derived betatrophin; Pancreas  -cell regeneration
Core Tip	Yi et al have characterized a secreted protein named betatrophin that potently regulates ?-cell proliferation. Evidently, betatrophin is identical to re-feeding-induced fat and liver protein, lipasin and atypical angiopoeitin-like 8, all of which were characterized as regulators of lipid homeostasis, by three independent groups of investigators. Yi et al were the first to demonstrate that hepatic expression of betatrophin in mice caused a dramatic surge in proliferation of the pancreatic???-cells with a concomitant improvement of their glucose tolerance. The discovery of a circulating hormone that specifically targets b-cell proliferation is a promising development towards a better clinical management of diabetes.
Publish Date	2013-12-20 16:49
Citation	Raghow R. Betatrophin: A liver-derived hormone for the pancreatic β-cell proliferation. World J Diabetes 2013; 4(6): 234-237 Available from: URL: http://www.wjgnet.com/1948-9358/full/v4/i6/234.htm DOI: http://dx.doi.org/10.4239/wjd.v4.i6.234
URL	http://www.wjgnet.com/1948-9358/full/v4/i6/234.htm
DOI	http://dx.doi.org/10.4239/wjd.v4.i6.234

Full Article (PDF)	WJD-4-234.pdf
Full Article (Word)	WJD-4-234.doc
Manuscript File	4939-Review.docx
Answering Reviewers	4939-Answering reviewers.pdf
Copyright License Agreement	4939-Copyright assignment.pdf
Peer-review Report	4939-Peer reviewer(s).pdf
Scientific Editor Work List	4939-Scientific editor work list.doc