Publication Name	World Journal of Gastroenterology
Manuscript ID	4951
Country	China

Received	2013-08-05 10:31
Peer-Review Started	2013-08-05 18:45
To Make the First Decision	2013-09-16 20:27
Return for Revision	2013-09-16 21:57
Revised
Second Decision	2013-12-03 21:03
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-12-04 06:29
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-12-30 08:06
Typeset the Manuscript	2014-02-18 09:11
Publish the Manuscript Online	2014-02-26 11:18

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Autobiography
Article Title	Chloride intracellular channel 1 regulates colon cancer cell migration and invasion through ROS/ERK pathway
Manuscript Source	Invited Manuscript
All Author List	Pan Wang, Yun Zeng, Tao Liu, Chao Zhang, Pei-Wu Yu, Ying-Xue Hao, Hua-Xin Luo and Gang Liu
Funding Agency and Grant Number	Funding Agency Grant Number “Eleventh Five-year Plan” for Medical Science Development of PLA 06MB243 National Natural Science Foundation of China 81101101 National Natural Science Foundation of China 51273165 Key Project of Chinese Ministry of Education 212149 Projects of Sichuan Province 2010SZ0294 Projects of Sichuan Province 2011JQ0032 Projects of Sichuan Province 12ZB038
Corresponding Author	Chao Zhang, Professor, Department of General Surgery and Minimally Invasive Gastrointestinal Surgery, Southwest Hospital, Third Military Medical University, No. 252, Garden West Road, Shapingba District, Chongqing 400038, China. zhangchao5642@163.com
Key Words	Colon cancer; Intracellular chloride channel 1; Hypoxia-reoxygenation; Reactive oxygen species; Extracellular signal-regulated kinase; Cancer invasion
Core Tip	Hypoxia-reoxygenation (H-R) treatment increases the intracellular reactive oxygen species (ROS) level to activate the MAPK/ERK pathway, resulting in the promotion of migration and invasion in colon cancer LOVO cells. Inhibition of chloride intracellular channel 1 (CLIC1) using specific inhibitor IAA94 can markedly decrease the H-R-enhanced ROS generation, migration, invasion and phosphorylation of ERK. The results presented in the current study suggest that CLIC1 is involved in the metastasis of colon cancer LOVO cells via regulating the ROS/ERK pathway in the H-R process.
Publish Date	2014-02-26 11:18
Citation	Wang P, Zeng Y, Liu T, Zhang C, Yu PW, Hao YX, Luo HX, Liu G. Chloride intracellular channel 1 regulates colon cancer cell migration and invasion through ROS/ERK pathway. World J Gastroenterol 2014; 20(8): 2071-2078
URL	http://www.wjgnet.com/1007-9327/full/v20/i8/2071.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i8.2071

Full Article (PDF)	WJG-20-2071.pdf
Full Article (Word)	WJG-20-2071.doc
Manuscript File	4951-Review.doc
Answering Reviewers	4951-Answering reviewer(s).pdf
Copyright License Agreement	4951-Copyright assignment.pdf
Peer-review Report	4951-Peer reviewer(s).pdf
Scientific Editor Work List	4951-Scientific editor work list.doc