Publication Name	World Journal of Gastroenterology
Manuscript ID	4953
Country	China

Received	2013-08-05 10:47
Peer-Review Started	2013-08-05 17:57
To Make the First Decision	2013-08-21 18:50
Return for Revision	2013-08-30 13:33
Revised	2013-09-23 13:46
Second Decision	2013-10-21 17:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-10-22 07:08
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-11-06 17:34
Typeset the Manuscript	2013-11-21 18:46
Publish the Manuscript Online	2013-12-11 16:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Decreased histone H2B monoubiquitination in malignant gastric carcinoma
Manuscript Source	Invited Manuscript
All Author List	Zi-Jing Wang, Jing-Lin Yang, Yi-Ping Wang, Jiang-Yan Lou, Jie Chen, Cong Liu and Lian-Di Guo
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Science and Technology of China 2011CB966200 Ministry of Science and Technology of China 2013CB911000 National Natural Science Foundation of China 30970950 National Natural Science Foundation of China 81071362 National Natural Science Foundation of China 31171319 Program for Changjiang Scholars and Innovative Research Team in University of Ministry of Education of China 2011SZ0002 Department of Science and Technology of Sichuan Province, China 2012JQ0005 Bureau of Science and Technology of Chengdu 11PPYB072SF
Corresponding Author	Cong Liu, PhD, Professor, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of the Ministry of Education, Department of Gynecology, West China Second University Hospital, Sichuan University, No.20, Section 3, Ren Min Nan Lu Road, Chengdu 610041, Sichuan Province, China. congliu@scu.edu.cn
Key Words	Gastric cancer; Epigenetics; Histone modification; H2B monoubiquination; Nuclear immunostaining
Core Tip	The abundant H2B monoubiquination (uH2B) modification detected by immunohistochemistry (IHC) in normal human gastric epithelium is decreased in malignant gastric cancer specimens, and the decreasing trend is correlated with decreased tumor differentiation, Lauren's classification intestinal-type, presence of lymph node metastasis, and TNM stage. Positive uH2B staining is associated with higher 5-year survival. Multivariate analysis identified uH2B modification level as an independent prognostic factor for gastric cancer-specific survival. Collectively, these findings indicate the clinical significance of IHC-detected uH2B differential staining patterns as a potential prognostic biomarker in early stage gastric cancer.
Publish Date	2013-12-11 16:13
Citation	Wang ZJ, Yang JL, Wang YP, Lou JY, Chen J, Liu C, Guo LD. Decreased histone H2B monoubiquitination in malignant gastric carcinoma. World J Gastroenterol 2013; 19(44): 8099-8107
URL	http://www.wjgnet.com/1007-9327/full/v19/i44/8099.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i44.8099

Full Article (PDF)	WJG-19-8099.pdf
Manuscript File	4953-Review.doc
Answering Reviewers	4953-Answering reviewers.pdf
Copyright License Agreement	4953-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4953-Language certificate.pdf
Peer-review Report	4953-Peer reviewer(s).pdf
Scientific Editor Work List	4953-Scientific editor work list.doc