Publication Name	World Journal of Gastroenterology
Manuscript ID	4969
Country	China

Received	2013-08-06 09:56
Peer-Review Started	2013-08-06 21:31
To Make the First Decision	2013-09-09 16:50
Return for Revision	2013-09-10 11:11
Revised	2013-10-08 15:45
Second Decision	2013-10-17 14:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-10-18 07:59
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-10-29 17:03
Typeset the Manuscript	2014-01-06 10:25
Publish the Manuscript Online	2014-01-20 17:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Pathology
Manuscript Type	Autobiography
Article Title	ALK gene copy number gain and its clinical significance in hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Shou-Wei Jia, Sha Fu, Fang Wang, Qiong Shao, Hong-Bing Huang and Jian-Yong Shao
Funding Agency and Grant Number
Corresponding Author	Jian-Yong Shao, MD, PhD, Department of Molecular Diagnostics, Sun Yat-Sen University Cancer Center, No.651 Dongfeng Road, Guangzhou 510060, Guangdong Province, China. shaojy@sysucc.org.cn
Key Words	Anaplastic lymphoma kinase gene; Hepatocellular carcinoma; Prognostic predictor
Core Tip	This study retrospectively analyzed the status and clinical significance of anaplastic lymphoma kinase (ALK) gene alterations in a relatively large number of hepatocellular carcinoma (HCC) patients. We used HCC tissue microarrays to detect ALK transcripts by fluorescent in situ hybridization. No positive cases of ALK gene rearrangements and ALK amplification were observed. However, we found that ALK gene copy number gain (ALK/CNG) was common in HCC (13.15%, 28/213). Our findings suggest that ALK/CNG may serve as a prognostic marker for HCC, especially in patients with advanced stage, grade Ⅲ pathology.
Publish Date	2014-01-20 17:10
Citation	Jia SW, Fu S, Wang F, Shao Q, Huang HB, Shao JY. ALK gene copy number gain and its clinical significance in hepatocellular carcinoma. World J Gastroenterol 2014; 20(1): 183-192
URL	http://www.wjgnet.com/1007-9327/full/v20/i1/183.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i1.183

Full Article (PDF)	WJG-20-183.pdf
Full Article (Word)	WJG-20-183.doc
Manuscript File	4969-Review.doc
Answering Reviewers	4969-Answering reviewers.pdf
Copyright License Agreement	4969-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4969-Language certificate.pdf
Peer-review Report	4969-Peer reviews.pdf
Scientific Editor Work List	4969-Scientific editor work list.doc