| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
New era for pancreatic endoscopic ultrasound: From imaging to molecular pathology of pancreatic cancer
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Livia Archibugi, Sabrina Gloria Giulia Testoni, Miriam Redegalli, Maria Chiara Petrone, Michele Reni, Massimo Falconi, Claudio Doglioni, Gabriele Capurso and Paolo Giorgio Arcidiacono |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Associazione Italiana Ricerca sul Cancro (AIRC) |
IG 17177 |
|
| Corresponding Author |
Gabriele Capurso, MD, PhD, Chief Doctor, Pancreato-Biliary Endoscopy and EUS Division, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milano 20132, Italy. capurso.gabriele@hsr.it |
| Key Words |
Endoscopic ultrasound; Pancreatic cancer; Ribonucleic acid; Deoxyribonucleic acid; Mutation; Molecular |
| Core Tip |
Surgical formalin-fixed-paraffin-embedded samples are not representative of all pancreatic ductal adenocarcinoma (PDAC) patients and it was proved how “pre-resection” fine-needle aspiration smears are a better deoxyribonucleic acid (DNA) source. endoscopic ultrasound (EUS) is therefore the recommended method to obtain tumour’s molecular signature analysis. However, important limitations of EUS-acquired samples are: intratumoral heterogeneity, tumoral cells total amount and lesional-to-non-lesional cell ratio. Furthermore, sample handling and stock change DNA and even more ribonucleic acid extraction efficiency, a current “hot topic” as also patient-derived xenografts or organoids generation. Optimization and standardization of procedures from EUS-guided biopsy to samples handling and molecular analyses are, therefore, essential to allow a “precision medicine” for PDAC. |
| Publish Date |
2019-11-15 07:45 |
| Citation |
Archibugi L, Testoni SGG, Redegalli M, Petrone MC, Reni M, Falconi M, Doglioni C, Capurso G, Arcidiacono PG. New era for pancreatic endoscopic ultrasound: From imaging to molecular pathology of pancreatic cancer. World J Gastrointest Oncol 2019; 11(11): 933-945 |
| URL |
https://www.wjgnet.com/1948-5204/full/v11/i11/933.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v11.i11.933 |
