Publication Name	World Journal of Gastroenterology
Manuscript ID	4978
Country	China

Received	2013-08-07 09:29
Peer-Review Started	2013-08-07 20:13
First Decision by Editorial Office Director
Return for Revision	2013-09-04 09:58
Revised	2013-09-25 08:19
Publication Fee Transferred
Second Decision by Editor	2013-11-04 18:11
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-11-05 11:07
Articles in Press
Edit the Manuscript by Language Editor	2013-11-19 11:16
Typeset the Manuscript	2013-12-01 19:30
Publish the Manuscript Online	2013-12-18 10:00

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Intestinal stem cell marker LGR5 expression during gastric carcinogenesis
Manuscript Source	Invited Manuscript
All Author List	Zhi-Xue Zheng, Yu Sun, Zhao-De Bu, Lian-Hai Zhang, Zi-Yu Li, Ai-Wen Wu, Xiao-Jiang Wu, Xiao-Hong Wang, Xiao-Jing Cheng, Xiao-Fang Xing, Hong Du and Jia-Fu Ji
Funding Agency and Grant Number	Funding Agency Grant Number Beijing Municipal Science and Technology Commission’s NOVA Program 2009BG-02 Beijing Municipal Health System Special funds of High-Level Medical Personnel Construction 2013-3-082
Corresponding Author	Dr. Jia-Fu Ji, MD, FACS, Department of Gastrointestinal Surgery, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Fu Cheng Road 52, Hai Dian District, Beijing 100142, China. jiafuj@gmail.com
Key Words	Leucine-rich repeat-containing G protein-coupled receptor 5; Cancer stem cell; Gastric cancer; Intestinal metaplasia; Tumorigenesis
Core Tip	This is the first study to evaluate the expression of leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5), a putative cancer stem cell marker, in progressive stages of gastric carcinogenesis. The observation of increasing LGR5 expression in human gastric cancer lesions, following the loss of differentiation (from dysplastic to gastric cancer cases) and risk of spread (metastatic cases), suggests that this receptor may represent an important biomarker for early detection of patients at higher risk for gastric tumorigenesis. The observed distinctive expression pattern of LGR5 in intestinal metaplasia suggests that these cells may represent a precancerous condition but not carcinoma precursors.
Publish Date	2013-12-18 10:00
Citation	Zheng ZX, Sun Y, Bu ZD, Zhang LH, Li ZY, Wu AW, Wu XJ, Wang XH, Cheng XJ, Xing XF, Du H, Ji JF. Intestinal stem cell marker LGR5 expression during gastric carcinogenesis. World J Gastroenterol 2013; 19(46): 8714-8721
URL	http://www.wjgnet.com/1007-9327/full/v19/i46/8714.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i46.8714

Full Article (PDF)	WJG-19-8714.pdf
Manuscript File	4978-Review.doc
Answering Reviewers	4978-Answering reviewers.pdf
Copyright License Agreement	4978-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4978-Language certificate.pdf
Peer-review Report	4978-Peer reviews.pdf