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Articles Published Processes
9/28/2019 10:12:50 AM | Browse: 1146 | Download: 2785
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Received |
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2019-06-19 00:46 |
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Peer-Review Started |
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2019-06-20 11:10 |
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First Decision by Editorial Office Director |
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2019-07-21 01:14 |
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Return for Revision |
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2019-07-24 08:46 |
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Revised |
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2019-07-26 00:11 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2019-08-23 10:16 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2019-08-24 04:45 |
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Articles in Press |
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2019-08-24 04:45 |
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Edit the Manuscript by Language Editor |
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2019-09-08 03:23 |
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Typeset the Manuscript |
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2019-09-27 07:36 |
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Publish the Manuscript Online |
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2019-09-28 10:12 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Zinc-α2-glycoprotein 1 attenuates nonalcoholic fatty liver by negatively regulating tumour necrosis factor-α
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ting Liu, Xin Luo, Zheng-Hong Li, Jun-Cheng Wu, Sheng-Zheng Luo and Ming-Yi Xu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81570547 |
| Development Program of China during the 13th Five-year Plan Period |
2017ZX10203202003005 |
| National Natural Science Foundation of China |
81770597 |
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| Corresponding Author |
Ming-Yi Xu, MD, Chief Doctor, Professor, Department of Gastroenterology, Shanghai General Hospital, No 100, Haining Rd, Shanghai 200080, China. xumingyi2014@163.com |
| Key Words |
Non-alcoholic fatty liver disease; Zinc-α2-glycoprotein 1; Tumour necrosis factor-α; Inflammation; Lipid metabolism; |
| Core Tip |
The expressions of zinc-α2-glycoprotein 1 (AZGP1) were significantly down-regulated in liver tissues of non-alcoholic fatty liver disease (NAFLD) patients and mice. In LO2 cells, AZGP1 had the effects of alleviating NAFLD by means of blocking tumour necrosis factor-α signaling mediated inflammation, intracellular lipid deposition, proliferation and apoptosis. AZGP1 treatment could attenuate NAFLD to some extent in mice model. So AZGP1 is suggested to be a novel promising therapeutic target for NAFLD. |
| Publish Date |
2019-09-28 10:12 |
| Citation |
Liu T, Luo X, Li ZH, Wu JC, Luo SZ, Xu MY. Zinc-α2-glycoprotein 1 attenuates nonalcoholic fatty liver by negatively regulating tumour necrosis factor-α. World J Gastroenterol 2019; 25(36): 5451-5468
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| URL |
https://www.wjgnet.com/1007-9327/full/v25/i36/5451.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i36.5451 |
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