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Articles Published Processes
12/30/2019 1:55:29 AM | Browse: 885 | Download: 2268
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Received |
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2019-06-15 08:54 |
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Peer-Review Started |
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2019-06-18 02:17 |
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To Make the First Decision |
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2019-08-06 02:51 |
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Return for Revision |
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2019-08-08 00:48 |
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Revised |
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2019-10-01 05:45 |
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Second Decision |
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2019-09-05 11:32 |
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Accepted by Journal Editor-in-Chief |
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2019-09-05 11:51 |
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Accepted by Executive Editor-in-Chief |
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2019-10-14 17:15 |
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Articles in Press |
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2019-10-14 17:15 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-10-22 02:43 |
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Typeset the Manuscript |
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2019-12-19 05:56 |
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Publish the Manuscript Online |
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2019-12-30 01:55 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
HIF-2α regulate CD44 to promote cancer stem cell activation in triple-negative breast cancer via PI3K/AKT/mTOR
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jie Bai, Wei-Bin Chen, Xiao-Yu Zhang, Xiao-Ning Kang, Li-Jun Jin, Hui Zhang and Zun-Yi Wang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Zun-Yi Wang, MD, Doctor, Doctor, Department of third Oncology, Cangzhou Central Hospital, NO.16, Xinhua Road West, Cangzhou 061001, Hebei Province, China. czwzy99@163.com |
| Key Words |
Breast cancer; Hypoxia-inducible factor-2α; Cancer stem cells; CD44; ; |
| Core Tip |
Cancer stem cells (CSCs) play an important role in tumor formation, growth, invasion, metastasis and recurrence. Hypoxia can promote the differentiation of various tumor cells, enable cells to acquire stem cell characteristics, and enhance tumor cell invasion and tumorigenicity. In the long-term chronic hypoxia of tumors, the major regulatory factor is hypoxia-inducible factor-2α (HIF-2α), which can promote the malignant biological behavior of tumors by activating its downstream target genes. Researches have shown that the effect of HIF-2α on tumor cells may be related to CD44, a marker for breast CSCs. In this study, breast cancer cell line MCF-7 and basal breast cancer cell line MDA-MB-231 were utilized to investigate the relationship between HIF-2α and CD44 gene expression and regulate HIF-2α to observe the expression of CD44. |
| Publish Date |
2019-12-30 01:55 |
| Citation |
Bai J, Chen WB, Zhang XY, Kang XN, Jin LJ, Zhang H, Wang ZY. HIF-2α regulate CD44 to promote cancer stem cell activation in triple-negative breast cancer via PI3K/AKT/Mtor. World J Stem Cells 2020; 12(1): 87-99 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i1/87.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i1.87 |
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