Publication Name	World Journal of Gastroenterology
Manuscript ID	49832
Country	Italy

Received	2019-06-17 00:34
Peer-Review Started	2019-06-17 04:02
First Decision by Editorial Office Director	2019-07-21 01:48
Return for Revision	2019-07-23 03:40
Revised	2019-08-09 06:19
Publication Fee Transferred
Second Decision by Editor	2019-09-06 12:13
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2019-09-09 06:00
Articles in Press	2019-09-09 06:00
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-10-25 09:29
Publish the Manuscript Online	2019-10-28 11:23

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Sustained virologic response to direct-acting antiviral agents predicts better outcomes in hepatitis C virus-infected patients: A retrospective study
Manuscript Source	Unsolicited Manuscript
All Author List	GianLuca Colussi, Debora Donnini, Rosario F Brizzi, Silvia Maier, Luca Valenti, Cristiana Catena, Alessandro Cavarape, Leonardo A Sechi and Giorgio Soardo
ORCID	Author(s) ORCID Number GianLuca Colussi http://orcid.org/0000-0003-1673-540X Debora Donnini http://orcid.org/0000-0003-4943-5825 Rosario F Brizzi http://orcid.org/0000-0001-5410-3775 Silvia Maier http://orcid.org/0000-0001-9672-4369 Luca Valenti http://orcid.org/0000-0001-8909-0345 Cristiana Catena http://orcid.org/0000-0001-5039-435X Alessandro Cavarape http://orcid.org/0000-0003-2726-5714 Leonardo A Sechi http://orcid.org/0000-0002-6242-0209 Giorgio Soardo http://orcid.org/0000-0003-3181-5651
Funding Agency and Grant Number
Corresponding Author	Giorgio Soardo, MD, Associate Professor, Department of Medicine, University of Udine, 1st floor, Building n.8, Piazzale Santa Maria della Misericordia 1, Udine 33100, Italy. giorgio.soardo@asuiud.sanita.fvg.it
Key Words	Direct-acting antiviral agents; Hepatitis C virus; Mixed cryoglobulinemia; Sustained virologic response; Cirrhosis; Survival analysis
Core Tip	The protective role of a sustained virologic response (SVR) achieved by direct-acting antiviral agents (DAAs) against the chronic consequences of hepatitis C virus (HCV) infection is not well established. We examined the occurrence of hepatocellular carcinoma (HCC) or death from any cause in a retrospective-prospective study at our tertiary academic hospital center for liver disease management. We confirmed that DAA treatment is very effective in inducing SVR in HCV-infected patients and in protecting patients against HCC development or death. However, a residual risk of HCC persists, particularly in patients with advanced liver disease or with extra-hepatic HCV-related complications.
Publish Date	2019-10-28 11:23
Citation	Colussi G, Donnini D, Brizzi RF, Maier S, Velenti L, Catena C, Cavarape A, Sechi LA, Soardo G. Sustained virologic response to direct-acting antiviral agents predicts better outcomes in hepatitis C virus-infected patients: A retrospective study. World J Gastroenterol 2019; 25(40): 6094-6106
URL	https://www.wjgnet.com/1007-9327/full/v25/i40/6094.htm
DOI	https://dx.doi.org/10.3748/wjg.v25.i40.6094

Full Article (PDF)	WJG-25-6094.pdf
Full Article (Word)	WJG-25-6094.docx
Manuscript File	49832-Review.docx
Answering Reviewers	49832-Answering reviewers.pdf
Audio Core Tip	49832-Audio core tip.mp3
Biostatistics Review Certificate	49832-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	49832-Conflict-of-interest statement.pdf
Copyright License Agreement	49832-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	49832-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	49832-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	49832-Language certificate.pdf
Supplementary Material	49832-Supplementary material.pdf
Peer-review Report	49832-Peer-review(s).pdf
Scientific Misconduct Check	49832-Scientific misconduct check.pdf
Scientific Editor Work List	49832-Scientific editor work list.pdf
CrossCheck Report	49832-CrossCheck Report.pdf