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Articles Published Processes
9/28/2019 10:12:50 AM | Browse: 1353 | Download: 2649
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Received |
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2019-06-17 00:21 |
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Peer-Review Started |
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2019-06-18 02:25 |
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First Decision by Editorial Office Director |
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2019-08-03 19:38 |
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Return for Revision |
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2019-08-07 00:25 |
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Revised |
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2019-08-13 14:42 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2019-08-23 10:09 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2019-08-24 04:48 |
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Articles in Press |
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2019-08-24 04:48 |
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Edit the Manuscript by Language Editor |
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2019-09-09 22:26 |
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Typeset the Manuscript |
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2019-09-27 07:26 |
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Publish the Manuscript Online |
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2019-09-28 10:12 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
CARMA3/NF-κB signaling contributes to the tumorigenesis of hepatocellular carcinoma and is inhibited by Sodium Aescinate
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hui Hou, Wei-Xiang Li, Xiao Cui, Da-Chen zhou, Bin Zhang and Xiao-Ping Geng |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Nature Science Foundation of High Education Institution of Anhui Province |
KJ2017A825 |
| Natural Science Foundation of Anhui Province |
1808085MH270 |
| Foundation of the Higher Education Institution of Henan Province |
16A320007 |
| “Huohua Jihua” Foundation of the Second Hospital of Anhui Medical University Science |
No.2015hhjh05 |
| Anhui Medical University Science Foundation |
2017xkj033 |
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| Corresponding Author |
Xiao-Ping Geng, MD, Director, Director, Professor, Department of Hepato-Pancreato-Biliary Surgery, Department of Surgery,, The First Affiliated Hospital of Anhui Medical University, No. 120 Wanshui Road, Gaoxin District, Hefei 230032, Anhui Province, China. xp_geng@163.net |
| Key Words |
CARMA3; Nuclear factor kappa-B; Sodium Aescinate; Hepatocellular carcinoma; Tumorigenesis; Liver cancer |
| Core Tip |
Hepatocellular carcinoma (HCC) ranked the sixth in the most common malignant tumors and is the most frequent primary liver cancer; nuclear factor kappa-B (NF-κB) signal pathway is commonly activated and exerts critical roles in the progression of HCC. Here, we hypothesized CARMA3 might play an oncogenic role in HCC by activating NF-κB, and explored the relationships between CARMA3 expression and clinicopathological characters. Furthermore, we found Sodium Aescinate, exerted anti-tumor effects possibly by inactivating CARMA3/NF-κB signaling. |
| Publish Date |
2019-09-28 10:12 |
| Citation |
Hou H, Li WX, Cui X, Zhou DC, Zhang B, Geng XP. CARMA3/NF-κB signaling contributes to the tumorigenesis of hepatocellular carcinoma and is inhibited by Sodium Aescinate. World J Gastroenterol 2019; 25(36): 5483-5493
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| URL |
https://www.wjgnet.com/1007-9327/full/v25/i36/5483.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i36.5483 |
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