Publication Name	World Journal of Gastroenterology
Manuscript ID	49837
Country	China

Received	2019-06-17 00:21
Peer-Review Started	2019-06-18 02:25
To Make the First Decision	2019-08-05 02:27
Return for Revision	2019-08-07 00:25
Revised	2019-08-13 14:42
Second Decision	2019-08-23 10:09
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2019-08-24 04:48
Articles in Press	2019-08-24 04:48
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-09-09 22:26
Typeset the Manuscript	2019-09-27 07:26
Publish the Manuscript Online	2019-09-28 10:12

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	CARMA3/NF-κB signaling contributes to the tumorigenesis of hepatocellular carcinoma and is inhibited by Sodium Aescinate
Manuscript Source	Unsolicited Manuscript
All Author List	Hui Hou, Wei-Xiang Li, Xiao Cui, Da-Chen zhou, Bin Zhang and Xiao-Ping Geng
ORCID	Author(s) ORCID Number Hui Hou http://orcid.org/0000-0003-0463-4783 Wei-Xiang Li http://orcid.org/0000-0003-2716-0672 Xiao Cui http://orcid.org/0000-0003-0409-6073 Da-Chen zhou http://orcid.org/0000-0003-3228-0206 Bin Zhang http://orcid.org/0000-0001-7052-908X Xiao-Ping Geng http://orcid.org/0000-0002-6219-6366
Funding Agency and Grant Number	Funding Agency Grant Number Nature Science Foundation of High Education Institution of Anhui Province KJ2017A825 Natural Science Foundation of Anhui Province 1808085MH270 Foundation of the Higher Education Institution of Henan Province 16A320007 “Huohua Jihua” Foundation of the Second Hospital of Anhui Medical University Science No.2015hhjh05 Anhui Medical University Science Foundation 2017xkj033
Corresponding Author	Xiao-Ping Geng, MD, Director, Director, Professor, Department of Hepato-Pancreato-Biliary Surgery, Department of Surgery,, The First Affiliated Hospital of Anhui Medical University, No. 120 Wanshui Road, Gaoxin District, Hefei 230032, Anhui Province, China. xp_geng@163.net
Key Words	CARMA3; Nuclear factor kappa-B; Sodium Aescinate; Hepatocellular carcinoma; Tumorigenesis; Liver cancer
Core Tip	Hepatocellular carcinoma (HCC) ranked the sixth in the most common malignant tumors and is the most frequent primary liver cancer; nuclear factor kappa-B (NF-κB) signal pathway is commonly activated and exerts critical roles in the progression of HCC. Here, we hypothesized CARMA3 might play an oncogenic role in HCC by activating NF-κB, and explored the relationships between CARMA3 expression and clinicopathological characters. Furthermore, we found Sodium Aescinate, exerted anti-tumor effects possibly by inactivating CARMA3/NF-κB signaling.
Publish Date	2019-09-28 10:12
Citation	Hou H, Li WX, Cui X, Zhou DC, Zhang B, Geng XP. CARMA3/NF-κB signaling contributes to the tumorigenesis of hepatocellular carcinoma and is inhibited by Sodium Aescinate. World J Gastroenterol 2019; 25(36): 5483-5493
URL	https://www.wjgnet.com/1007-9327/full/v25/i36/5483.htm
DOI	https://dx.doi.org/10.3748/wjg.v25.i36.5483

Full Article (PDF)	WJG-25-5483.pdf
Full Article (Word)	WJG-25-5483.docx
Manuscript File	49837-Review_Edited.docx
Answering Reviewers	49837-Answering reviewers.pdf
Audio Core Tip	49837-Audio core tip.mp3
Biostatistics Review Certificate	49837-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	49837-Conflict-of-interest statement.pdf
Copyright License Agreement	49837-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	49837-Grant application form(s).pdf
Institutional Review Board Approval Form or Document	49837-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	49837-Language certificate.pdf
Peer-review Report	49837-Peer-review(s).pdf
Scientific Misconduct Check	49837-Scientific misconduct check.pdf
Scientific Editor Work List	49837-Scientific editor work list.pdf
CrossCheck Report	49837-CrossCheck report.pdf