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9/7/2019 4:43:36 AM | Browse: 219 | Download: 324
Publication Name World Journal of Gastroenterology
Manuscript ID 49851
Country/Territory South Korea
2019-06-17 00:25
Peer-Review Started
2019-06-17 05:55
To Make the First Decision
2019-07-22 03:28
Return for Revision
2019-07-24 00:51
2019-07-30 06:15
Second Decision
2019-08-16 09:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-08-19 13:32
Articles in Press
2019-08-19 13:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-09-04 03:22
Publish the Manuscript Online
2019-09-07 04:43
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Observational Study
Article Title Tenofovir is a more suitable treatment than entecavir for chronic hepatitis B patients carrying naturally occurring rtM204I mutations
Manuscript Source Unsolicited Manuscript
All Author List Won Hyeok Choe, Ki Jeong Kim, So Young Lee, Yu Min Choi, So Young Kwon, Jeong Han Kim and Bum Joon Kim
Author(s) ORCID Number
Won Hyeok Choe http://orcid.org/0000-0002-8019-5412
Ki Jeong Kim http://orcid.org/0000-0002-5132-1774
So Young Lee http://orcid.org/0000-0002-9638-893X
Yu Min Choi http://orcid.org/0000-0003-4709-3155
So Young Kwon http://orcid.org/0000-0003-4290-1950
Jeong Han Kim http://orcid.org/0000-0002-8383-8524
Bum Joon Kim http://orcid.org/0000-0003-0085-6709
Funding Agency and Grant Number
Corresponding Author Bum Joon Kim, PhD, Professor, Department of Biomedical Sciences, Microbiology and Immunology, Liver Research Institute, Cancer Research Institute and SNUMRC, College of Medicine, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul 03080, South Korea. kbumjoon@snu.ac.kr
Key Words Chronic hepatitis B; Entecavir; Hepatitis B virus; Liver fibrosis; Mutation; Tenofovir
Core Tip Hepatitis B virus (HBV) DNA polymerase mutations have been known to be prevalent in treatment-naïve chronic hepatitis B (CHB) patients infected with HBV genotype C2 strains. The newly developed locked nucleotide probe based real-time PCR method could discriminate the naturally-occurring rtM204I mutations from wild type with high sensitivity in treatment-naïve patients. Multivariate analyses showed that the naturally-occurring rtM204I variants were more frequently pre-existed in patients with liver fibrosis, and the pre-existence of the naturally-occurring rtM204I variants were significantly associated with incomplete viral response to nucleos(t)ide analogues. Tenofovir is a more suitable nucleos(t)ide analogues than entecavir for treatment-naïve CHB patients carrying the naturally occurring rtM204I mutations.
Publish Date 2019-09-07 04:43
Citation Choe WH, Kim KJ, Lee SY, Choi YM, Kwon SY, Kim JH, Kim BJ. Tenofovir is a more suitable treatment than entecavir for chronic hepatitis B patients carrying naturally occurring rtM204I mutations. World J Gastroenterol 2019;25(33): 4985-4998
Url https://www.wjgnet.com/1007-9327/full/v25/i33/4985.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i33.4985
Full Article (PDF) WJG-25-4985.pdf
Full Article (Word) WJG-25-4985.docx
Manuscript File 49851-Review.docx
Answering Reviewers 49851-Answering reviewers.pdf
Audio Core Tip 49851-Audio core tip.MP3
Biostatistics Review Certificate 49851-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 49851-Conflict-of-interest statement.pdf
Copyright License Agreement 49851-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 49851-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 49851-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 49851-Language certificate.pdf
Peer-review Report 49851-Peer-review(s).pdf
Scientific Misconduct Check 49851-Scientific misconduct check.pdf
Scientific Editor Work List 49851-Scientific editor work list.pdf