Publication Name	World Journal of Gastroenterology
Manuscript ID	49924
Country	United States

Received	2019-06-26 00:18
Peer-Review Started	2019-06-26 08:09
To Make the First Decision	2019-07-22 02:12
Return for Revision	2019-07-22 07:48
Revised	2019-07-25 13:48
Second Decision	2019-08-02 10:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-08-07 09:27
Articles in Press	2019-08-07 09:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-09-11 08:32
Publish the Manuscript Online	2019-09-12 08:50

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Hepatic senescence, the good and the bad
Manuscript Source	Invited Manuscript
All Author List	Nazmul Huda, Gang Liu, Honghai Hong, Shengmin Yan, Bilon Khambu and Xiao‐Ming Yin
ORCID	Author(s) ORCID Number Nazmul Huda http://orcid.org/0000-0002-7788-8621 Gang Liu http://orcid.org/0000-0001-5917-9605 Honghai Hong http://orcid.org/0000-0003-2138-9118 Shengmin Yan http://orcid.org/0000-0003-4012-9557 Bilon Khambu http://orcid.org/0000-0002-9432-2064 Xiao‐Ming Yin http://orcid.org/0000-0002-8576-6093
Funding Agency and Grant Number
Corresponding Author	Xiao‐Ming Yin, FAASLD, MD, PhD, Full Professor, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 975 W Walnut St, Indianapolis, IN 46202, United States. xmyin@iupui.edu
Key Words	Senescence; Senescence associated secretory phenotype; Hepatocyte; Cholangiocyte; Hepatic stellate cell; Cell cycle arrest
Core Tip	The liver is a vital organ for metabolic regulation and plays a major role in the nutrient utilization of the whole body. Although scientists have paid much attention to hepatic senescence, the precise mechanisms in, and the contribution of cellular senescence to liver diseases have yet to be clearly defined. In this review, we have summarized the mechanism of senescence in general and in the liver. We have also discussed whether hepatocellular senescence is beneficial or harmful to the liver in the light of published findings.
Publish Date	2019-09-12 08:50
Citation	Huda N, Liu G, Hong H, Yan S, Khambu B, Yin X-M. Hepatic senescence, the good and the bad. World J Gastroenterol 2019; 25(34): 5069-5081
URL	https://www.wjgnet.com/1007-9327/full/v25/i34/5069.htm
DOI	https://dx.doi.org/10.3748/wjg.v25.i34.5069

Full Article (PDF)	WJG-25-5069.pdf
Full Article (Word)	WJG-25-5069.docx
Manuscript File	49924-Review.docx
Answering Reviewers	49924-Answering reviewers.pdf
Audio Core Tip	49924-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	49924-Conflict-of-interest statementn.pdf
Copyright License Agreement	49924-Copyright license agreement.pdf
Peer-review Report	49924-Peer-review(s).pdf
Scientific Misconduct Check	49924-Google-MA RY-2.png
Scientific Misconduct Check	49924-Scientific misconduct check.pdf
Scientific Editor Work List	49924-Scientific editor work list.pdf