Publication Name	World Journal of Gastroenterology
Manuscript ID	5004
Country	Italy

Received	2013-08-08 10:08
Peer-Review Started	2013-08-08 12:35
To Make the First Decision	2013-09-02 16:22
Return for Revision	2013-09-04 10:33
Revised	2013-09-10 21:22
Second Decision	2013-09-17 09:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-09-17 11:43
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-10-21 08:28
Publish the Manuscript Online	2013-12-18 09:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Field of Vision
Article Title	High intensity focused ultrasound, liver disease and bridging therapy
Manuscript Source	Invited Manuscript
All Author List	Mearini Luigi
Funding Agency and Grant Number
Corresponding Author	Luigi Mearini, MD, Urologist-Oncologist, Deparment of Urology, University of Perugia, Azienda Ospedaliera di Perugia, Sant'Andrea delle Fratte, 06100 Perugia, Italy. luigi.mearini@tin.it
Key Words	High-intensity focused ultrasound; Hepatocellular carcinoma; Liver transplantation; Bridging therapy; Waiting list
Core Tip	High-intensity focused ultrasound (HIFU) is a non-invasive modality used to destroy tissue. It has been used to treat unresectable advanced stages of hepatocellular carcinoma (HCC) and liver metastases. In some HCC cases, liver transplantation has become one of the best treatments because it removes the tumour and the underlying liver disease such as cirrhosis. The so-called "bridging therapy" has the aim of controlling disease burden for patients who are on the organ transplant waiting list. Here, we discuss various treatment options including transarterial chemoembolisation and radiofrequency ablation, and we examine the utility of HIFU as a safe and effective method of bridging therapy that can reduce the dropout rate of patients who are on the liver transplant waiting list.
Publish Date	2013-12-18 09:53
Citation	Luigi M. High intensity focused ultrasound, liver disease and bridging therapy. World J Gastroenterol 2013; 19(43): 7494-7499
URL	http://www.wjgnet.com/1007-9327/full/v19/i43/7494.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i43.7494

Full Article (PDF)	WJG-19-7494.pdf
Manuscript File	5004-Review.doc
Answering Reviewers	5004-Answering reviewers.pdf
Copyright License Agreement	5004-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5004-Language certificate.pdf
Peer-review Report	5004-Peer reviews.pdf
Scientific Editor Work List	5004-Scientific editor work list.doc