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Articles Published Processes
10/14/2019 10:47:07 AM | Browse: 1292 | Download: 2724
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Received |
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2019-07-16 16:09 |
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Peer-Review Started |
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2019-07-17 08:18 |
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First Decision by Editorial Office Director |
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2019-08-02 09:26 |
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Return for Revision |
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2019-08-16 02:41 |
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Revised |
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2019-08-30 12:27 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2019-09-12 09:55 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2019-09-13 04:13 |
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Articles in Press |
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2019-09-13 04:13 |
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Edit the Manuscript by Language Editor |
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2019-09-24 12:06 |
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Typeset the Manuscript |
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2019-10-14 07:39 |
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Publish the Manuscript Online |
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2019-10-14 10:47 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Sirtuin 1 alleviates the endoplasmic reticulum stress-mediated apoptosis of intestinal epithelial cells in ulcerative colitis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Meng-Ting Ren, Meng-Li Gu, Xin-Xin Zhou, Mo-Sang Yu, Hang-Hai Pan, Feng Ji and Chen-Yan Ding |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Nature Science Foundation of China |
81600414 |
| the Natural Science Foundation of Zhejiang Province |
LQ16H030001 |
| Zhejiang TCM Science and Technology Project |
2016ZA123 |
| Zhejiang TCM Science and Technology Project |
2018ZA013 |
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| Corresponding Author |
Xin-Xin Zhou, MD, Attending Doctor, Department of Gastroenterology, The First Affiliated Hospital,College of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. zhouxinxin@zju.edu.cn |
| Key Words |
Sirtuin 1; Endoplasmic reticulum stress; Apoptosis; Ulcerative colitis; Intestinal barrier; |
| Core Tip |
The purpose of this article is to investigate the role of sirtuin 1 (SIRT1) in intestinal epithelial cells (IECs) in ulcerative colitis (UC) in a UC coculture model and in mice with dextran sodium sulfate (DSS)-induced colitis. It was found that SIRT1 activation contributes to enhanced intestinal barrier and reduced apoptosis of IECs via the suppression of the endoplasmic reticulum stress-mediated apoptosis-associated molecules CCAAT/enhancer-binding protein homologous protein and caspase-12. SIRT1 activation may be a potential therapeutic strategy for UC. |
| Publish Date |
2019-10-14 10:47 |
| Citation |
Ren MT, Gu ML, Zhou XX, Yu MS, Pan HH, Ji F, Ding CY. Sirtuin 1 alleviates the endoplasmic reticulum stress-mediated apoptosis of intestinal epithelial cells in ulcerative colitis. World J Gastroenterol 2019; 25(38): 5800-5813 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i38/5800.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i38.5800 |
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