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Articles Published Processes
12/17/2019 2:30:58 AM | Browse: 1010 | Download: 2116
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Received |
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2019-07-26 21:16 |
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Peer-Review Started |
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2019-07-26 21:16 |
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To Make the First Decision |
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2019-08-19 02:11 |
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Return for Revision |
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2019-08-19 06:22 |
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Revised |
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2019-10-20 20:22 |
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Second Decision |
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2019-10-25 07:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-10-28 23:58 |
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Articles in Press |
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2019-10-28 23:58 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-11-07 06:37 |
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Typeset the Manuscript |
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2019-12-04 06:39 |
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Publish the Manuscript Online |
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2019-12-17 02:30 |
| ISSN |
1948-9358 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Influence of 10-(6-plastoquinonyl) decyltriphenylphosphonium on free-radical homeostasis in the heart and blood serum of rats with streptozotocin-induced hyperglycemia
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Aleksandr A Agarkov, Tatyana N Popova and Yana G Boltysheva |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Aleksandr A Agarkov, PhD, Assistant Professor, Department of Medical Biochemistry and Microbiology, Voronezh State University, Voronezh, Russia, 1 Universitetskaya pl., Voronezh 394018, Russia. agalalek@mail.ru |
| Key Words |
Diabetes mellitus; Free radical oxidation; Antioxidants; ; ; |
| Core Tip |
The results of this research allow suggesting that the mitochondria targeted antioxidant — 10-(6-plastoquinonyl) decyltriphenylphosphonium (SkQ1), might be considered as a perspective substance for incorporation into the antioxidant therapy of type 2DM. The experimentally revealed ability of this compound to lower the intensity of free-radical processes, acting as the key component of the pathogenesis of the type 2DM, may serve as the reason for this conclusion. Thus, after the introduction of SkQ1 — to the animals with streptozotocin induced hyperglycemia, the values of the biochemiluminescence parametres reflecting the FO intensity, the concentration of diene conjugates and carbonyl products of protein oxidation, and the aconitate hydratase activity and citrate content changed towards the control values. At the same time, the activity level of the antioxidant enzyme — superoxide dismutase and catalase, changed to the direction of norm. |
| Publish Date |
2019-12-17 02:30 |
| Citation |
Agarkov AA, Popova TN, Boltysheva YG. Influence of 10-(6-plastoquinonyl) decyltriphenylphosphonium on free-radical homeostasis in the heart and blood serum of rats with streptozotocin-induced hyperglycemia. World J Diabetes 2019; 10(12): 546-559 |
| URL |
https://www.wjgnet.com/1948-9358/full/v10/i12/546.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v10.i12.546 |
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