ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Basic Study |
Article Title |
Nucleus tractus solitarius mediates hyperalgesia induced by chronic pancreatitis in rats
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Yang Bai, Ying-Biao Chen, Xin-Tong Qiu, Yan-Bing Chen, Li-Tian Ma, Ying-Qi Li, Hong-Ke Sun, Ming-Ming Zhang, Ting Zhang, Tao Chen, Bo-Yuan Fan, Hui Li and Yun-Qing Li |
ORCID |
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Funding Agency and Grant Number |
Funding Agency |
Grant Number |
National Natural Science Foundations of China |
81620108008 |
Major Research and Development Project of Hainan Province |
2018153 |
Training Program for Scientific Research Scholars of Fujian Provincial Health and Family Planning Commission |
2018-ZQN-74 |
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Corresponding Author |
Yun-Qing Li, PhD, Professor, Department of Anatomy, Histology and Embryology & K. K. Leung Brain Research Centre, Fourth Military Medical University, No. 169 West Chang-le Road, Xi'an 710032, Shaanxi Province,, China. deptanat@fmmu.edu.cn |
Key Words |
Rat; Chronic pancreatitis; Visceral hypersensitivity; The nucleus tractus solitarius; Excitatory synaptic transmission; |
Core Tip |
This study investigates the role of the nucleus tractus solitarius (NTS) in the pathogenesis of visceral hypersensitivity in a rat model of chronic pancreatitis (CP). We demonstrated that CP rats exhibited potentiated excitatory synaptic transmission within the caudal NTS. This potentiation may be mediated by enhanced glutamate release and the recruitment of membrane glutamate receptors. Inhibiting both the excitatory synaptic transmission and neural activity of caudal NTS neurons alleviated visceral hypersensitivity in CP rats. Our results suggest the caudal NTS as a primary central site that processes pancreatic pain, as well as a potential therapeutic target for the treatment of chronic visceral pain in patients with CP. |
Publish Date |
2019-10-28 11:23 |
Citation |
Bai Y, Chen YB, Chen YB, Ma LT, Li YQ, Sun HK, Qiu XT, Zhang T, Chen T, Fan BY, Li H, Li YQ. Nucleus tractus solitarius mediates hyperalgesia induced by chronic pancreatitis in rats. World J Gastroenterol 2019; 25(40): 6077-6093 |
URL |
https://www.wjgnet.com/1007-9327/full/v25/i40/6077.htm |
DOI |
https://dx.doi.org/10.3748/wjg.v25.i40.6077 |