| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Nucleoside diphosphate-linked moiety X-type motif 15 R139C genotypes impact the 6-thioguanine nucleotide cut-off levels to predict thiopurine-induced leukopenia in Crohn’s disease patients
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xia Zhu, Kang Chao, Miao Li, Wen Xie, Hong Zheng, Jin-Xin Zhang, Pin-Jin Hu, Min Huang, Xiang Gao and Xue-Ding Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the 111 project |
B16047 |
| the National Science Foundation of China |
81473283, 81173131, 81573507, and 81320108027 |
| the Natural Major Projects for science and technology development from Science and Technology Ministry of China |
2012ZX09506001-004 |
| he Major Scientific and Technological Project of Guangdong Province |
2011A080300001 |
| Guangdong Provincial Key Laboratory of Construction Foundation |
2011A060901014 |
| Science and Technology Program of Guangzhou |
2014J4100179 |
| The National Key Research and Development Program |
No.2016YFC0905000 |
|
| Corresponding Author |
Xue-Ding Wang, PharmD, Professor, Teacher, Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University Cancer Center, No. 132 Waihuan Dong Road, Guangzhou University City, Guangzhou 510006, Guangdong Province, China. wangxd@mail.sysu.edu.cn |
| Key Words |
Crohn’s disease; Thioguanine nucleotide levels; Nucleoside diphosphate-linked moiety X-type motif 15; Thiopurine-induced leukopenia; ; |
| Core Tip |
Thiopurine-induced leukopenia (TIL), a life-threatening toxicity in inflammatory bowel disease, occurs with high frequency in Asia. Although nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) significantly increases the prediction sensitivity of TIL, more than 50% of cases cannot be predicted by this mutation. The potential use of steady-state thioguanine nucleotide (6TGN) levels to predict TIL has been explored for decades, but no decisive conclusion has been reached. Can we increase the predictive sensitivity based on 6TGN by subgrouping patients according to their NUDT15 genotypes? Yes! According to our research, applying 6TGN levels to adjust thiopurine therapies based on NUDT15 is strongly recommended. |
| Publish Date |
2019-10-14 10:47 |
| Citation |
Zhu X, Chao K, Li M, Xie W, Zheng H, Zhang JX, Hu PJ, Huang M, Gao X, Wang XD. Nucleoside diphosphate-linked moiety X-type motif 15 R139C genotypes impact the 6-thioguanine nucleotide cut-off levels to predict thiopurine-induced leukopenia in Crohn’s disease patients. World J Gastroenterol 2019; 25(38): 5850-5861 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i38/5850.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i38.5850 |
