Publication Name	World Journal of Translational Medicine
Manuscript ID	5040
Country	United States

Received	2013-08-10 21:35
Peer-Review Started	2013-08-12 10:34
To Make the First Decision	2013-09-09 14:23
Return for Revision	2013-09-12 12:01
Revised	2013-10-11 01:00
Second Decision	2013-11-20 11:22
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-21 05:31
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-12-17 13:47
Publish the Manuscript Online	2014-01-06 20:25

ISSN	2220-6132 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Chemistry, Applied
Manuscript Type	Autobiography
Article Title	Molecular recognition of live methicillin-resistant staphylococcus aureus cells using DNA aptamers
Manuscript Source	Invited Manuscript
All Author List	Diane Turek, Dimitri Van Simaeys, Judith Johnson, Ismail Ocsoy and Weihong Tan
Funding Agency and Grant Number
Corresponding Author	Weihong Tan, Distinguished Professor, Department of Chemistry, Center for Research at Bio/Nano Interface, University of Florida, 100 Farrior Hall at 100 Fletcher Drive, Gainesville, FL 32611, United States. tan@chem.ufl.edu
Key Words	Aptamer; Methicillin-resistant Staphylococcus aureus; Gram-positve bacteria; Cell recognition
Core Tip	Methicillin-resistant Staphylococcus aureus (MRSA) is a nosocomial bacterium that has developed resistance to beta-lactam antibiotics and can now be contracted in community settings. A tool that would enable the recognition of MRSA through its membrane structure could lead to new therapeutic approaches to eradicate the MRSA superbug. This paper presents four MRSA aptamers that can be easily modified as molecular probes for bioanalysis or antibiotics-free therapy. The Cell-SELEX technology was used to develop target-specific aptamers and binding studies of those aptamers were performed by flow cytometry on a panel of clinical strains. A total of four aptamers that bind to MRSA were obtained.
Publish Date	2014-01-06 20:25
Citation	Turek D, Van Simaeys D, Johnson J, Ocsoy I, Tan W. Molecular recognition of live methicillin-resistant staphylococcus aureus cells using DNA aptamers. World J Transl Med 2013; 2(3): 67-74
URL	http://www.wjgnet.com/2220-6132/full/v2/i3/67.htm
DOI	http://dx.doi.org/10.5528/wjtm.v2.i3.67

Full Article (PDF)	WJTM-2-67.pdf
Full Article (Word)	WJTM-2-67.doc
Manuscript File	5040-Review.doc
Answering Reviewers	5040-Answering reviewers.pdf
Copyright License Agreement	5040-Copyright assignment.pdf
Peer-review Report	5040-Peer review(s).pdf
Scientific Editor Work List	5040-Scientific editor work list.doc