Publication Name	World Journal of Gastroenterology
Manuscript ID	5048
Country	United States

Received	2013-08-12 11:15
Peer-Review Started	2013-08-12 15:20
To Make the First Decision	2013-09-02 16:20
Return for Revision	2013-09-04 11:14
Revised	2013-09-11 01:41
Second Decision	2013-09-17 09:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-09-17 11:44
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-10-15 17:18
Publish the Manuscript Online	2013-11-13 08:37

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Genetics & Heredity
Manuscript Type	Topic Highlights
Article Title	Impact of exome sequencing in inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	Christopher J Cardinale, Judith R Kelsen, Robert N Baldassano and Hakon Hakonarson
Funding Agency and Grant Number	Funding Agency Grant Number Senior Research Award from the Crohn’s to Cardinale CJ Colitis Foundation of America to Hakonarson H special purpose fund from the Edmunds Family Foundation for Ulcerative Colitis Studies to Baldassano RN
Corresponding Author	Hakon Hakonarson, MD, PhD, Director, Center for Applied Genomics, Children's Hospital of Philadelphia, Abramson Research Center Suite 1216, 3615 Civic Center Blvd, Philadelphia, PA 19104, United States. hakonarson@chop.edu
Key Words	Sequencing; Exome; Genetics; Inflammatory bowel disease
Core Tip	The genetic understanding of inflammatory bowel disease (IBD) has progressed over the last twenty years as new technologies and analytic techniques have become available. The nascent revolution in next-generation sequencing will enable us to sequence the exome - all the protein coding genes in the genome - in thousands of individuals. This review discusses the implications of this new approach for diagnosis in very early onset IBD and as a tool to gain understanding of the hereditary basis of the common polygenic form of the disease at the population level.
Publish Date	2013-11-13 08:37
Citation	Cardinale CJ, Kelsen JR, Baldassano RN, Hakonarson H. Impact of exome sequencing in inflammatory bowel disease. World J Gastroenterol 2013; 19(40): 6721-6729
URL	http://www.wjgnet.com/1007-9327/full/v19/i40/6721.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i40.6721

Full Article (PDF)	WJG-19-6721.pdf
Manuscript File	5048-Review.docx
Answering Reviewers	5048-Answering reviewers.pdf
Copyright License Agreement	5048-Copyright assignment.pdf
Peer-review Report	5048-Peer reviews.pdf
Scientific Editor Work List	5048-Scientific editor work list.doc