| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Yaron Niv, Doron Boltin, Marisa Halpern, Miriam Cohen, Zohar Levi, Alex Vilkin, Sara Morgenstern, Vahig Manugian, Erica St Lawrence, Pascal Gagneux, Sukhwinder Kaur, Poonam Sharma, Surinder K Batra and Samuel B Ho |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institute of Neurological Disorders and Stroke |
P30 NS047101 |
| Neurosciences Microscopy Shared Facility, UCSD from the G Harold and Leila Y Mathers Charitable Foundation |
CSD018 |
| NIH center |
DK080506 |
|
| Corresponding Author |
Samuel B Ho, MD, Chief, Department of Medicine, VA San Diego Healthcare System and University of California San Diego, 3350 La Jolla Village Drive, San Diego, CA 92161, United States. samuel.ho2@va.gov |
| Key Words |
Idiopathic ulcer; Helicobacter pylori; Glycosylation; Peptic ulcer disease; Mucosal cytoprotection |
| Core Tip |
Peptic ulcers are diverse in origin, and the proportion of idiopathic gastric ulcers not related to Helicobacter pylori infection or non-steroidal inflammatory drug therapy is increasing. Membrane-bound mucin proteins in peptic ulcer has not been described previously, and are important for understanding of ulcer pathogenesis and subsequently treatment. Major findings of this paper include the observation that MUC17 staining was significantly decreased in idiopathic ulcer cases, whereas MUC1 mucin expression was increased. Idiopathic ulcers also demonstrated higher sialic acid mucin residue staining. These alterations in mucin core proteins and sialylation patterns may be associated with differences in epithelial cytoprotection, and therefore may play a role in ulcer pathogenesis. |
| Publish Date |
2014-10-29 19:34 |
| Citation |
Niv Y, Boltin D, Halpern M, Cohen M, Levi Z, Vilkin A, Morgenstern S, Manugian V, St Lawrence E, Gagneux P, Kaur S, Sharma P, Batra SK, Ho SB. Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers. World J Gastroenterol 2014; 20(40): 14913-14920 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i40/14913.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i40.14913 |
