Publication Name	World Journal of Diabetes
Manuscript ID	50603
Country	Nigeria

Received	2019-08-06 21:09
Peer-Review Started	2019-08-06 21:10
To Make the First Decision	2019-09-23 00:59
Return for Revision	2019-09-25 07:35
Revised	2019-12-07 07:46
Second Decision	2020-01-13 10:05
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-01-13 21:51
Articles in Press	2020-01-13 21:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-02-25 08:45
Publish the Manuscript Online	2020-02-28 10:31

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Physiology
Manuscript Type	Basic Study
Article Title	Vitamin C ameliorated cardiac autonomic neuropathy in type 2 diabetic rats
Manuscript Source	Unsolicited Manuscript
All Author List	Temitope Deborah Fabiyi-Edebor
ORCID	Author(s) ORCID Number Temitope Deborah Fabiyi-Edebor http://orcid.org/0000-0002-9444-8484
Funding Agency and Grant Number
Corresponding Author	Temitope Deborah Fabiyi-Edebor, PhD, Senior Lecturer, Department of Physiology, Afe Babalola University, Kilometres 8.5 Afe Babalola Way, Ado 5454, Ekiti, Nigeria. debbyteefab@gmail.com
Key Words	Vitamin C; Oxidative stress; Heart rate variability; Tyrosine Hydroxylase; Autonomic nerve; Neuropathy
Core Tip	This study reveals that Vitamin C maintained normal heart rate variability, blood pressure and sympathetic tone in type 2 diabetic rats. Thus, preventing the symptoms of cardiac autonomic neuropathy. This is done via mechanisms related to downregulation of oxidative stress, inflammation and dyslipidaemia. Vitamin C may therefore possess cardio-autonomic nerve protection potential and may be used to prevent the development of cardiac autonomic neuropathy in type 2 diabetic subjects.
Publish Date	2020-02-28 10:31
Citation	Fabiyi-Edebor TD. Vitamin C ameliorated cardiac autonomic neuropathy in type 2 diabetic rats. World J Diabetes 2020; 11(3): 52-65
URL	https://www.wjgnet.com/1948-9358/full/v11/i3/52.htm
DOI	https://dx.doi.org/10.4239/wjd.v11.i3.52

Full Article (PDF)	WJD-11-52.pdf
Full Article (Word)	WJD-11-52.docx
The ARRIVE Guidelines	50603-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	50603-Review.docx
Answering Reviewers	50603-Answering reviewers.pdf
Audio Core Tip	50603-Audio core tip.mp3
Biostatistics Review Certificate	50603-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	50603-Conflict-of-interest statement.pdf
Copyright License Agreement	50603-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	50603-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	50603-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	50603-Language certificate.pdf
Peer-review Report	50603-Peer-review(s).pdf
Scientific Misconduct Check	50603-Scientific misconduct check.pdf
Scientific Editor Work List	50603-Scientific editor work list.pdf
CrossCheck Report	50603-CrossCheck Report.pdf