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Articles Published Processes
12/27/2019 7:49:26 AM | Browse: 584 | Download: 1017
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Received |
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2019-08-05 17:27 |
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Peer-Review Started |
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2019-08-05 17:27 |
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To Make the First Decision |
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2019-09-02 01:36 |
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Return for Revision |
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2019-09-06 08:18 |
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Revised |
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2019-09-25 17:26 |
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Second Decision |
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2019-11-05 03:47 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-11-07 20:58 |
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Articles in Press |
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2019-11-07 20:58 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-11-18 21:47 |
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Typeset the Manuscript |
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2019-12-21 07:29 |
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Publish the Manuscript Online |
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2019-12-27 07:49 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Pathological abnormalities in splenic vasculature in non-cirrhotic portal hypertension: Its relevance in the management of portal hypertension
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shahana Gupta, Biju Pottakkat, Surendra Kumar Verma, Raja Kalayarasan, Sandip Chandrasekar A and Ajith Ananthakrishna Pillai |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Biju Pottakkat, MD, Professor, Department of Surgical Gastroenterology, JIPMER, Super-speciality Block 4th Floor, Pondycherry 605006, India. bijupottakkat@gmail.com |
| Key Words |
Portal hypertensive vasculopathy; Non cirrhotic portal hypertension; Splenic vasculature; Hyperdynamic circulation; Shunt surgery; |
| Core Tip |
Portal hypertensive vasculopathy is well investigated in cirrhotics. Raised portal pressure and hyperdynamic circulation are thought to be the underlying cause. Pathological changes in splenic vein are similar in cirrhotic and non-cirrhotic portal hypertensive (NCPH). They are not primarily due to venous degenerative changes and are similar to those observed in pulmonary vasculature in pulmonary hypertension. Portal hypertensive in NCPH should be viewed as systemic and pulmonary hypertension equivalent in the gastrointestinal tract. We show that these pathological venous changes in NCPH are observed in greater proportion of patients in the delayed presentation group (P < 0.003). Interventions to reduce portal pressure should therefore be initiated at diagnosis of NCPH. The damage to the vasculature starts early and can be prevented from progressing to venous thrombosis and its sequelae if early surgical intervention to reduce portal pressure is initiated. |
| Publish Date |
2019-12-27 07:49 |
| Citation |
Gupta S, Pottakkat B, Verma SK, Kalayarasan R, Chandrasekar A S, Pillai AA. Pathological abnormalities in splenic vasculature in non-cirrhotic portal hypertension: Its relevance in the management of portal hypertension. World J Gastrointest Surg 2020; 12(1): 1-8 |
| URL |
https://www.wjgnet.com/1948-9366/full/v12/i1/1.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v12.i1.1 |
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