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Articles Published Processes
9/1/2014 10:54:00 AM | Browse: 1326 | Download: 1370
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Received |
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2013-08-13 08:22 |
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Peer-Review Started |
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2013-08-13 14:08 |
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To Make the First Decision |
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2013-08-21 18:39 |
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Return for Revision |
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2013-08-22 19:19 |
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Revised |
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Second Decision |
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2013-09-16 14:00 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2013-09-17 05:38 |
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Articles in Press |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2013-09-29 14:13 |
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Publish the Manuscript Online |
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2013-10-31 15:06 |
Category |
Dermatology |
Manuscript Type |
Editorial |
Article Title |
Molecular mimicry in cutaneous autoimmune diseases
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Manuscript Source |
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All Author List |
Fabrizio Guarneri and Claudio Guarneri |
Funding Agency and Grant Number |
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Corresponding Author |
Fabrizio Guarneri, MD, Professor, Department of Clinical and Experimental Medicine, University of Messina, AOU Policlinico “G. Martino”, Via Consolare Valeria 1, 98125 Messina, Italy. f.guarneri@tiscali.it |
Key Words |
Molecular mimicry; Dermatology; Autoimmunity; Bioinformatics; Amino acid sequence homology |
Core Tip |
Molecular mimicry between microbial and human proteins is often used by pathogens to control biosynthetic/regulatory pathways of infected cells and elude immune reaction of host. In predisposed subjects, immune response against non-self molecules can, because of molecular mimicry, turn against self antigens and trigger autoimmune diseases. This mechanism, which explains the specific epidemiological link between some infections and some autoimmune diseases, is known and experimentally confirmed in several disciplines, but much less studied in dermatology. Bioinformatics can greatly help and boost research by quickly and almost inexpensively identifying molecules most probably involved in triggering autoimmunity via molecular mimicry. |
Publish Date |
2013-10-31 15:06 |
Citation |
Guarneri F, Guarneri C. Molecular mimicry in cutaneous autoimmune diseases. World J Dermatol 2013; 2(4): 36-43 |
URL |
http://www.wjgnet.com/2218-6190/full/v2/i4/36.htm |
DOI |
http://dx.doi.org/10.5314/wjd.v2.i4.36 |
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