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3/12/2020 11:28:25 AM | Browse: 70 | Download: 77
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 50639
Country/Territory China
2019-08-01 04:18
Peer-Review Started
2019-08-01 04:20
To Make the First Decision
2019-08-29 00:43
Return for Revision
2019-09-02 09:30
2020-01-12 00:48
Second Decision
2019-10-24 01:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-02-06 17:59
Articles in Press
2020-02-06 17:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-02-11 03:28
Typeset the Manuscript
2020-02-26 08:59
Publish the Manuscript Online
2020-03-12 11:28
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Basic Study
Article Title Changes in extracellular matrix in different stages of colorectal cancer and their effects on proliferation of cancer cells
Manuscript Source Unsolicited Manuscript
All Author List Zhu-Lin Li, Zhen-Jun Wang, Guang-Hui Wei, Yong Yang and Xiao-Wan Wang
Author(s) ORCID Number
Zhu-Lin Li http://orcid.org/0000-0001-7935-3981
Zhen-Jun Wang http://orcid.org/0000-0001-6885-9354
Guang-Hui Wei http://orcid.org/0000-0002-5671-0357
Yong Yang http://orcid.org/0000-0001-8824-156X
Xiao-Wan Wang http://orcid.org/0000-0002-8064-1654
Funding Agency and Grant Number
Corresponding author Zhen-Jun Wang, MD, Chief Doctor, Professor, Surgeon, Surgical Oncologist, Department of General Surgery, Beijing Chaoyang Hospital affiliated to Capital Medical University, No. 8 Gongtinan Lu, Chaoyang District, Beijing 100020, China. drzhenjun@163.com
Keywords Colorectal cancer; Extracellular matrix; Tumor microenvironment; Proliferation; Collagen; Tumorigenesis
Core Tip Extracellular matrix remodels during the occurrence and development of tumor. In order to study the changes of extracellular matrix, we obtained the extracellular matrix of colorectal cancer (CRC) by acellular technology. We found the type I collagen, matrix metalloproteinase-2 and matrix metalloproteinase-9 increased in the CRC tissue, but type IV collagen and tissue inhibitor of metalloproteinase-3 decreased in the CRC tissue. Furthermore, we co-cultured the extracellular matrix and HT 29 cancer cells in vivo and in vitro, and we found the cancer extracellular matrix more conducive for the growth of cancer cells than normal tissue extracellular matrix.
Publish Date 2020-03-12 11:28
Citation Li ZL, Wang ZJ, Wei GH, Yong Y, Wang XW. Changes in extracellular matrix in different stages of colorectal cancer and their effects on proliferation of cancer cells. World J Gastrointest Oncol 2020; 12(3): 267-275
Url https://www.wjgnet.com/1948-5204/full/v12/i3/267.htm
DOI https://dx.doi.org/10.4251/wjgo.v12.i3.267
Full Article (PDF) WJGO-12-267.pdf
Full Article (Word) WJGO-12-267.docx
Manuscript File 50639-Review_WangTQ.docx
Answering Reviewers 50639-Answering reviewers.pdf
Audio Core Tip 50639-Audio core tip.wav
Biostatistics Review Certificate 50639-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 50639-Conflict-of-interest statement.pdf
Copyright License Agreement 50639-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 50639-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 50639-Institutional review board statement.pdf
Peer-review Report 50639-Peer-review(s).pdf
Scientific Misconduct Check 50639-Scientific misconduct check.pdf
Scientific Editor Work List 50639-Scientific editor work list.pdf