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Articles Published Processes
3/12/2020 11:28:25 AM | Browse: 919 | Download: 1570
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Received |
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2019-08-01 04:18 |
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Peer-Review Started |
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2019-08-01 04:20 |
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To Make the First Decision |
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2019-08-29 00:43 |
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Return for Revision |
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2019-09-02 09:30 |
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Revised |
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2020-01-12 00:48 |
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Second Decision |
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2019-10-24 01:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-02-06 17:59 |
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Articles in Press |
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2020-02-06 17:59 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-02-11 03:28 |
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Typeset the Manuscript |
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2020-02-26 08:59 |
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Publish the Manuscript Online |
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2020-03-12 11:28 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Changes in extracellular matrix in different stages of colorectal cancer and their effects on proliferation of cancer cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhu-Lin Li, Zhen-Jun Wang, Guang-Hui Wei, Yong Yang and Xiao-Wan Wang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Zhen-Jun Wang, MD, Chief Doctor, Professor, Surgeon, Surgical Oncologist, Department of General Surgery, Beijing Chaoyang Hospital affiliated to Capital Medical University, No. 8 Gongtinan Lu, Chaoyang District, Beijing 100020, China. drzhenjun@163.com |
| Key Words |
Colorectal cancer; Extracellular matrix; Tumor microenvironment; Proliferation; Collagen; Tumorigenesis |
| Core Tip |
Extracellular matrix remodels during the occurrence and development of tumor. In order to study the changes of extracellular matrix, we obtained the extracellular matrix of colorectal cancer (CRC) by acellular technology. We found the type I collagen, matrix metalloproteinase-2 and matrix metalloproteinase-9 increased in the CRC tissue, but type IV collagen and tissue inhibitor of metalloproteinase-3 decreased in the CRC tissue. Furthermore, we co-cultured the extracellular matrix and HT 29 cancer cells in vivo and in vitro, and we found the cancer extracellular matrix more conducive for the growth of cancer cells than normal tissue extracellular matrix. |
| Publish Date |
2020-03-12 11:28 |
| Citation |
Li ZL, Wang ZJ, Wei GH, Yong Y, Wang XW. Changes in extracellular matrix in different stages of colorectal cancer and their effects on proliferation of cancer cells. World J Gastrointest Oncol 2020; 12(3): 267-275 |
| URL |
https://www.wjgnet.com/1948-5204/full/v12/i3/267.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v12.i3.267 |
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