Publication Name	World Journal of Hepatology
Manuscript ID	5072
Country	Hungary

Received	2013-08-13 09:21
Peer-Review Started	2013-08-13 15:46
To Make the First Decision	2013-09-02 16:16
Return for Revision	2013-09-03 19:11
Revised	2013-09-27 04:07
Second Decision	2013-10-15 14:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-10-16 10:24
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-10-23 18:34
Publish the Manuscript Online	2013-10-25 08:47

ISSN	1948-5182 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	Lipotoxicity in the liver
Manuscript Source	Invited Manuscript
All Author List	Veronika Zámbó, Laura Simon-Szabó, Péter Szelényi, Éva Kereszturi, Gábor Bánhegyi and Miklós Csala
Funding Agency and Grant Number	Funding Agency Grant Number Hungarian Scientific Research Fund OTKA 104113 Hungarian Scientific Research Fund OTKA 106060 Hungarian Research and Technological Innovation Fund KMR_12-1-2012-0074
Corresponding Author	Gábor Bánhegyi, MD, PhD, Professor, Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Tűzoltó u. 37-47, H-1444 Budapest,
Key Words	Saturated fatty acid; Lipotoxicity; Steatosis; Lipoapoptosis; Endoplasmic reticulum stress
Core Tip	Surplus of free fatty acids contributes to hepatic injuries in obesity and type 2 diabetes. Intracellular accumulation of fatty acyl-CoA causes oxidative and endoplasmic reticulum (ER) stress, which lead to cell death, inflammation and fibrosis. Steatohepatosis is the consequence of an intensive fat synthesis, aiming to reduce the metabolic burden. The higher toxicity of saturated vs unsaturated fatty acids is partly due to a limited capacity of the liver cells to insert them into triglycerides. Moreover, increased membrane saturation triggers the ER stress response though a unique mechanism, which aggravates the metabolic derangements and liver injuries.
Publish Date	2013-10-25 08:47
Citation	Zámbó V, Simon-Szabó L, Szelényi P, Kereszturi é, Bánhegyi G, Csala M. Lipotoxicity in the liver. World J Hepatol 2013; 5(10): 550-557
URL	http://www.wjgnet.com/1948-5182/full/v5/i10/550.htm
DOI	http://dx.doi.org/10.4254/wjh.v5.i10.550

Full Article (PDF)	WJH-5-550.pdf
Manuscript File	5072-Review.doc
Answering Reviewers	5072-Answering reviews.pdf
Copyright License Agreement	5072-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5072-Language certificate.pdf
Peer-review Report	5072-Peer review(s).pdf
Scientific Editor Work List	5072-Scientific editor work list.doc