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Articles Published Processes
11/7/2019 1:35:59 AM | Browse: 832 | Download: 1956
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Received |
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2019-08-08 09:36 |
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Peer-Review Started |
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2019-08-08 09:36 |
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To Make the First Decision |
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2019-09-19 06:52 |
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Return for Revision |
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2019-09-20 06:44 |
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Revised |
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2019-09-26 19:21 |
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Second Decision |
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2019-10-16 12:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-10-17 06:17 |
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Articles in Press |
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2019-10-17 06:17 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-10-27 13:50 |
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Typeset the Manuscript |
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2019-11-05 02:26 |
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Publish the Manuscript Online |
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2019-11-07 01:35 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Yinchenhao decoction attenuates obstructive jaundice-induced liver injury and hepatocyte apoptosis by suppressing the protein kinase RNA-like endoplasmic reticulum kinase-induced pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Li Wu, Zhong-Lian Li, Xi-Bo Zhang and Hao Liu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81273952 |
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| Corresponding Author |
Zhong-Lian Li, MD, PhD, Chief Doctor, Doctor, Doctor, Professor, Surgeon, Department of Hepatobiliary and Pancreatic Surgery(2), Tianjin Nankai Hospital, 6 Changjiang Street, Nankai District, Tianjin 300100, China. nkyylzl@163.com |
| Key Words |
Yinchenhao decoction; Obstructive jaundice; Liver injury; Apoptosis; Protein kinase RNA-like endoplasmic reticulum kinase; CCAAT/enhancer-binding protein homologous protein |
| Core Tip |
Chronic biliary obstruction results in ischaemia and hypoxia of hepatocytes and leads to apoptosis. The protein kinase RNA-like endoplasmic reticulum kinase (PERK)-induced apoptotic pathway is the main and important way, however, its role in liver injury and hepatocyte apoptosis remains unclear. Yinchenhao decoction (YCHD) can alleviate liver injury and apoptosis, whether YCHD can attenuates obstructive jaundice (OJ)-induced liver injury and hepatocyte apoptosis by inhibiting the PERK-induced pathway is still unknown. In this research study, we found that OJ induced liver injury and hepatocyte apoptosis by activating the PERK- CCAAT/enhancer-binding protein homologous protein (CHOP)-Growth arrest and DNA damage-inducible protein 34 (GADD34) pathway and upregulating the B cell lymphoma/leukemia-2 related X protein (Bax)/ B cell lymphoma/leukemia-2 (Bcl-2) ratio. YCHD attenuated these changes by inhibiting the PERK-CHOP-GADD34 pathway and Bax/Bcl-2 ratio. |
| Publish Date |
2019-11-07 01:35 |
| Citation |
Wu YL, Li ZL, Zhang XB, Liu H. Yinchenhao decoction attenuates obstructive jaundice-induced liver injury and hepatocyte apoptosis by suppressing the protein kinase RNA-like endoplasmic reticulum kinase-induced pathway. World J Gastroenterol 2019; 25(41): 6205-6221 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i41/6205.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i41.6205 |
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