Publication Name	World Journal of Gastroenterology
Manuscript ID	5083
Country	China

Received	2013-08-14 10:46
Peer-Review Started	2013-08-14 16:52
First Decision by Editorial Office Director
Return for Revision	2013-09-03 19:34
Revised	2013-09-08 21:35
Publication Fee Transferred
Second Decision by Editor	2013-10-14 09:57
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-10-14 13:27
Articles in Press
Edit the Manuscript by Language Editor	2013-10-17 18:04
Typeset the Manuscript	2013-11-14 09:41
Publish the Manuscript Online	2013-12-18 09:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Case Report
Article Title	Unusual early-stage pancreatic sarcomatoid carcinoma
Manuscript Source	Invited Manuscript
All Author List	Chuan-Li Ren, Ping Jin, Chong-Xu Han, Qin Xiao, Dao-Rong Wang, Lin Shi, Da-Xin Wang and Hui Chen
Funding Agency and Grant Number	Funding Agency Grant Number China Postdoctoral Science Foundation 2013M541699 Social Development of Jiangsu Province, China BE2012705 Foundation of Northern Jiangsu People’s Hospital Yzucms201213
Corresponding Author	Hui Chen, MD, Geratology Department, Northern Jiangsu People’s Hospital and Clinical Medical College of Yangzhou University, No. 98 Western Nantong Road, Yangzhou 225001, Jiangsu Province, China. chenhuiyangzhou@163.com
Key Words	Sarcomatoid carcinoma of the pancreas; Transforming growth factorβ1; Epithelial-to mesenchymal transition; Interleukin-11; Vimentin
Core Tip	We herein report a case of an early-stage sarcomatoid carcinoma of the pancreas (SCP) involving successful treatment and a good prognosis. The plasma transforming growth factor (TGF)β1 and interleukin-11 levels were obviously increased according to enzyme-linked immunosorbent assay. Immunohistochemical analysis was positive for pan-cytokeratin, cytokeratin 8/18, and vimentin and negative for CD68 and lysozyme. The pathogenetic mechanism of this case shows that TGFβ1 may regulate the epithelial-to-mesenchymal transition in SCP. This case is also the first to show that TGFβ1 may regulate the epithelial-to-mesenchymal transition in early-stage SCP.
Publish Date	2013-12-18 09:53
Citation	Ren CL, Jin P, Han CX, Xiao Q, Wang DR, Shi L, Wang DX, Chen H. Unusual early-stage pancreatic sarcomatoid carcinoma. World J Gastroenterol 2013; 19(43): 7820-7824
URL	http://www.wjgnet.com/1007-9327/full/v19/i43/7820.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i43.7820

Full Article (PDF)	WJG-19-7820.pdf
Manuscript File	5083-Review.doc
Answering Reviewers	5083-Awersing reviews.pdf
Copyright License Agreement	5083-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5083-Language certificate.pdf
Peer-review Report	5083-Peer review(s).pdf
Scientific Editor Work List	5083-Scientific editor work list.doc